The relationship between mindfulness and empathy with the oxytocinergic system in persons with schizophrenia spectrum disorders: a proof-of-concept randomized controlled trial (OXYGEN)

• Kerem Böge ^[3] ; Niklas Bergmann ^[3] ; Marco Zierhut ^[3] ; Inge Hahne ^[3] ; Alice Braun ^[3] ; Julia Kraft ^[3] ; Ingmar Conell ^[3] ; Thi Minh Tam Ta ^[3] ; Neil Thomas ^[1] ; Paul Chadwick ^[2] ; Stephan Ripke ^[3] ; Eric Hahn ^[3]
  1. [1] Swinburne University of Technology

     Swinburne University of Technology

     Australia

     
  2. [2] University of Bath

     University of Bath

     Reino Unido

     
  3. [3] Universitätsmedizin Berlin

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• Localización: International journal of clinical and health psychology, ISSN 1697-2600, Vol. 24, Nº. 3, 2024, págs. 281-290
• Idioma: inglés
• DOI: 10.1016/j.ijchp.2024.100503
• Enlaces
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• Resumen

  • Background The present study explored the feasibility and acceptability as well as the impact of mindfulness-based group therapy (MBGT) on oxytocin levels (OXT) and clinical parameters in outpatients with schizophrenia spectrum disorders (SSD).

    Methods In a randomized-controlled design, outpatients with SSD (N = 48) were assigned to either MBGT in addition to German university-level treatment as usual (MBGT+TAU; n = 25) or TAU (n = 23). At baseline and at four-week post-intervention, clinical parameters and OXT levels were determined.

    Results Results indicate high feasibility and acceptance with a 95.7% adherence- and 94% retention- rate of MBGT in SSD. While no significant changes in empathy were observed, MBGT+TAU demonstrated a significant reduction in positive symptoms (Positive and Negative Syndrom Scale) compared to TAU at post-intervention. OXT levels were significantly increased in MBGT+TAU at post-intervention, suggesting a potential link between mindfulness and the oxytocinergic system in SSD. Additionally, improvements in various clinical parameters were indicated.

    Conclusion The study contributes to the growing evidence supporting feasibility, acceptability, and positive effects of MBGT in outpatients with SSD, emphasizing the need for further research to solidify these findings. Overall, this work sheds first evidence on the intersection of mindfulness, oxytocin, and clinical outcomes in SSD.

• Referencias bibliográficas
  • Addington, D., Addington, J., Maticka-Tyndale, E., & Joyce, J. (1992). Reliability and validity of a depression rating scale for schizophrenics....
  • Baron-Cohen, S., & Wheelwright, S. (2004). The empathy quotient: an investigation of adults with Asperger syndrome or high functioning...
  • Bellosta-Batalla, M., Blanco-Gandía, M. C., Rodríguez-Arias, M., Cebolla, A., Perez-Blasco, J., & Moya-Albiol, L. (2020). Increased salivary...
  • Bighelli, I., Wallis, S., Reitmeir, C., Schwermann, F., Salahuddin, N. H., & Leucht, S. (2023). Effects of psychological treatments on...
  • Boge, K., Catena, D., & Hahn, E. (2022). Achtsamkeitsbasierte Interventionen für Menschen mit psychotischen Storungen: ein Überblick über...
  • Boge, K., & Hahn, E. (2021). SENSE - Achtsamkeit bei psychotischen Storungen. Achtsamkeit bei psychotischen Storungen. Ein Gruppentherapiemanual...
  • Boge, K., Hahne, I., Bergmann, N., Wingenfeld, K., Zierhut, M., Thomas, N., Ta, T. M. T., Bajbouj, M., & Hahn, E. (2021). Mindfulness-based...
  • Boge, K., Karadza, A., Fuchs, L. M., Ehlen, F., Ta, T. M. T., Thomas, N., … Hahn, E. (2020a). Mindfulness-Based Interventions for In-Patients...
  • Boge, K., Schaeuffele, C., Jacobsen, P., Chadwick, P., Ergen, E., Hahne, I., … Hahn, E. (2020b). Validation of the German Version of the Southampton...
  • Boge, K., Thomas, N., & Jacobsen, P. (2021). Is Mindfulness for Psychosis harmful? Deconstructing a myth. The British Journal Of Psychiatry...
  • Centeno, R. P. R. (2020). Effect of mindfulness on empathy and self-compassion: an adapted MBCT program on filipino college students. Behavioral...
  • Chadwick, P. (2006). Person-based cognitive therapy for distressing psychosis. John Wiley & Sons.
  • Chadwick, P., Hember, M., Symes, J., Peters, E., Kuipers, E., & Dagnan, D. (2008). Responding mindfully to unpleasant thoughts and images:...
  • Czobor, P., Sebe, B., Acsai, K., Barabassy, A., Laszlovszky, I., Nemeth, G., … Leucht, S. (2022). What Is the minimum clinically important...
  • Davis, M. (1980). Self Report Measures for Love and Compassion Research: Empathy INTERPERSONAL REACTIVITY INDEX (IRI). JSAS Catalog of Selected...
  • Dollfus, S., Mach, C., & Morello, R. (2016). Self-Evaluation of Negative Symptoms: A Novel Tool to Assess Negative Symptoms. Schizophrenia...
  • Gaebel, W., Hasan, A., & Falkai, P. (2019). S3-Leitlinie Schizophrenie. Springer-Verlag. Gillanders, D. T., Bolderston, H., Bond, F. W.,...
  • Goh, K. K., Chen, C. H., & Lane, H. Y. (2021). Oxytocin in Schizophrenia: Pathophysiology and Implications for Future Treatment. International...
  • Harris, P. A., Taylor, R., Minor, B. L., Elliott, V., Fernandez, M., O’Neal, L., McLeod, L., Delacqua, G., Delacqua, F., Kirby, J., Duda,...
  • Heidenreich, T., Grober, C., & Michalak, J. (2015). Achtsamkeitsbasierte kognitive Therapie. Zeitschrift für Klinische Psychologie und...
  • Hu, Z., Wen, Y., Wang, Y., Lin, Y., Shi, J., Yu, Z., … Wang, Y. (2022). Effectiveness of mindfulness-based interventions on empathy: A meta-analysis....
  • Huppert, J. D., & Smith, T. E. (2005). Anxiety and schizophrenia: the interaction of subtypes of anxiety and psychotic symptoms. CNS spectrums,...
  • Jacobsen, P., Hodkinson, K., Peters, E., & Chadwick, P. (2018). A systematic scoping review of psychological therapies for psychosis within...
  • Jacobsen, P., Peters, E., & Chadwick, P. (2016). Mindfulness-Based Crisis Interventions for patients with psychotic symptoms on acute...
  • Jansen, J. E., Gleeson, J., Bendall, S., Rice, S., & Alvarez-Jimenez, M. (2020). Acceptance- and mindfulness-based interventions for persons...
  • Juckel, G., Schaub, D., Fuchs, N., Naumann, U., Uhl, I., Witthaus, H., Hargarter, L., Bierhoff, H. W., & Brüne, M. (2008). Validation...
  • Kay, S. R., Fiszbein, A., & Opler, L. A. (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin,...
  • Korann, V., Jacob, A., Lu, B., Devi, P., Thonse, U., Nagendra, B., Maria Chacko, D., Dey, A., Padmanabha, A., Shivakumar, V., Dawn Bharath,...
  • Kubzansky, L. D., Mendes, W. B., Appleton, A. A., Block, J., & Adler, G. K. (2012). A heartfelt response: Oxytocin effects on response...
  • Lancaster, G. A., Dodd, S., & Williamson, P. R. (2004). Design and analysis of pilot studies: recommendations for good practice. Journal...
  • Lawrence, E. J., Shaw, P., Baker, D., Baron-Cohen, S., & David, A. S. (2004). Measuring empathy: reliability and validity of the Empathy...
  • Linnen, A. M., Ellenbogen, M. A., Cardoso, C., & Joober, R. (2012). Intranasal oxytocin and salivary cortisol concentrations during social...
  • Liu, Y. C., Li, I. L., & Hsiao, F. H. (2021). Effectiveness of mindfulness-based intervention on psychotic symptoms for patients with...
  • Love, T. M. (2014). Oxytocin, motivation and the role of dopamine. Pharmacology, Biochemistry, And Behavior, 119, 49–60. https://doi.org/10.1016/j.pbb.2013.06.011
  • Marder, S. R., & Galderisi, S. (2017). The current conceptualization of negative symptoms in schizophrenia. World Psychiatry : Official...
  • Mavituna, S., Hahn, E., Hahne, I., Bergmann, N., Pijnenborg, M., Ta, T. M. T., … Boge, K. (2023). Compassion-based approaches: a systematic...
  • Morris, E. M., Johns, L. C., & Oliver, J. E. (2013). Acceptance and commitment therapy and mindfulness for psychosis. John Wiley &...
  • Nasrallah, H., Morosini, P., & Gagnon, D. D. (2008). Reliability, validity and ability to detect change of the Personal and Social Performance...
  • National Institute for Health and Care Excellence (NICE). (2014). Psychosis and Schizophrenia in Adults: Treatment and Management. NICE Clinical...
  • Neumann, I. D., Maloumby, R., Beiderbeck, D. I., Lukas, M., & Landgraf, R. (2013). Increased brain and plasma oxytocin after nasal and...
  • Page, A. C., Hooke, G. R., & Morrison, D. L. (2007). Psychometric properties of the Depression Anxiety Stress Scales (DASS) in depressed...
  • Paulus, C. (2009). Der Saarbrücker Personlichkeitsfragebogen SPF (IRI) zur Messung von Empathie. Psychometrische Evaluation der deutschen...
  • Peled-Avron, L., Abu-Akel, A., & Shamay-Tsoory, S. (2020). Exogenous effects of oxytocin in five psychiatric disorders: a systematic review,...
  • Reich, D., Evans, S., Nelson, B., Hickey, T., & O’Shea, M. (2021). Evidence map of mindfulness for stages of psychosis: state of the literature...
  • Ridderinkhof, A., de Bruin, E. I., Brummelman, E., & Bogels, S. M. (2017). Does mindfulness meditation increase empathy? An experiment....
  • Sabe, M., Kohler, R., Perez, N., Sauvain-Sabe, M., Sentissi, O., Jermann, F., … Boge, K. (2024). Mindfulness-based interventions for patients...
  • Sabe, M., Sentissi, O., & Kaiser, S. (2019). Meditation-based mind-body therapies for negative symptoms of schizophrenia: Systematic review...
  • Sabe, M., Zhao, N., Crippa, A., & Kaiser, S. (2021). Antipsychotics for negative and positive symptoms of schizophrenia: dose-response...
  • Samson, C., & Mallindine, C. (2014). The feasibility and effectiveness of running mindfulness groups in an early intervention in psychosis...
  • Schneider, F., Harter, M., & Schorr, S. (2017). S3-leitlinie/nationale versorgungsleitlinie unipolare depression. Springer-Verlag.
  • Shonin, E., Van Gordon, W., & Griffiths, M. D. (2014). Do mindfulness-based therapies have a role in the treatment of psychosis? Australian...
  • Stang, A., & Baethge, C. (2018). Imbalance p values for baseline covariates in randomized controlled trials: a last resort for the use...
  • Tan, L. B., Lo, B. C., & Macrae, C. N. (2014). Brief mindfulness meditation improves mental state attribution and empathizing. PloS one,...
  • Wang, Y., Fan, L., Zhu, Y., Yang, J., Wang, C., Gu, L., Zhong, S., Huang, Y., Xie, X., & Zhou, H. (2019). Neurogenetic mechanisms of self-compassionate...
  • Zierhut, M., Bergmann, N., Hahne, I., Wohlthan, J., Kraft, J., Braun, A., … Boge. (2024). The combination of oxytocin and mindfulness-based...