Connectivity of BA46 involvement in the executive control of language

• Alfredo Ardila ^[1] ; Byron Bernal ^[2] ; Monica Rosselli ^[3]
  1. [1] Florida International University

     Florida International University

     Estados Unidos

     
  2. [2] Miami Children's Hospital

     Miami Children's Hospital

     Estados Unidos

     
  3. [3] Florida Atlantic University

     Florida Atlantic University

     Estados Unidos

     

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• Localización: Psicothema, ISSN-e 1886-144X, ISSN 0214-9915, Vol. 28, Nº. 1, 2016, págs. 26-31
• Idioma: inglés
• DOI: 10.7334/psicothema2015.174
• Títulos paralelos:
  • Estudio de la conectividad del AB46 en el control ejecutivo del lenguaje
• Enlaces
  • Texto completo (pdf)
• Dialnet Métricas: 2 Citas
• Resumen
  • español

    Antecedentes: la comprensión de las funciones de diferentes áreas cerebrales representa una de las mayores empresas de las neurociencias contemporáneas. Los estudios contemporáneos con neuroimágenes sugieren que las funciones cognitivas se asocian con redes más que con áreas específicas. El propósito de este estudio fue analizar la conectividad del área de Brodmann 46 (BA46) (circunvolución frontal media anterior) con relación al lenguaje. Método: se llevó a cabo un meta-análisis para determinar el circuito o red lingüística en la cual participa BA46. Se utilizó la base de datos Brainmap; se incluyeron 19 artículos correspondientes a 60 condiciones experimentales con un total de 245 sujetos. Resultados: nuestros resultados sugieren un papel central de BA46 en la red del lenguaje. BA46 participa en un “sistema frontal de producción del lenguaje” (o sistema de Broca extendido). La conectividad hallada es también congruente con una participación menor en la semántica y la comprensión del lenguaje. Conclusiones: se concluye que BA46 juega un papel central en el sistema de producción del lenguaje, muy probablemente relacionado con su control ejecutivo.

  • English

    Background: Understanding the functions of different brain areas has represented a major endeavor of contemporary neurosciences. Modern neuroimaging developments suggest cognitive functions are associated with networks rather than with specific areas. Objectives. The purpose of this paper was to analyze the connectivity of Brodmann area (BA) 46 (anterior middle frontal gyrus) in relation to language. Methods: A meta-analysis was conducted to assess the language network in which BA46 is involved. The DataBase of Brainmap was used; 19 papers corresponding to 60 experimental conditions with a total of 245 subjects were included. Results: Our results suggest the core network of BA46. The localization and modules involved suggest BA46 participation in a “frontal language production system” (or extended Broca’s system). The depicted BA46 connectivity is also concordant with a minor role in language semantics and language understanding. Conclusion: It was concluded that BA46 plays a central role in the language production system, most likely related to its executive control

• Referencias bibliográficas
  • Abrahams, S., Goldstein, L. H., Simmons, A., Brammer, M. J., Williams, S. C., Giampietro, V. P., Andrew, C. M., & Leigh, P. N. (2003)....
  • Ardila, A. (1999). The role of insula in language: An unsettled question. Aphasiology, 13(1), 79-87.
  • Ardila, A. (2008). On the evolutionary origins of executive functions. Brain and Cognition , 68(1), 92-99.
  • Ardila, A. (2014). Aphasia Handbook. Miami, FL: Florida International University. https://aalfredoardila.files.wordpress.com/2013/07/ardila-a-2014-aphasia-handbook-miami-fl-florida-international-university2.pdf....
  • Ardila, A., Bernal, B., & Rosselli, M. (2014). Participation of the insula in language revisited: A meta-analytic connectivity study....
  • Ardila, A., Bernal, B., & Rosselli, M. (2015). Language and visual perception associations: Meta-analytic connectivity modeling of Brodmann...
  • Basho, S., Palmer, E. D., Rubio, M. A., Wulfeck, B., & Müller, R. A. (2007). Effects of generation mode in fMRI adaptations of semantic...
  • Bedny, M., & Thompson-Schill, S. L. (2006). Neuroanatomically separable effects of imageability and grammatical class during singleword...
  • Benson, D. F., & Ardila, A. (1996). Aphasia: A clinical perspective. New York: Oxford University Press.
  • Berthier, M. L. (2000). Transcortical aphasias. Psychology Press.
  • Bonelli, R. M., & Cummings, J. L. (2007). Frontal-subcortical circuitry and behavior. Dialogues in Clinical Neuroscience, 9(2), 141.
  • Booth, J. R., Burman, D. D., Meyer, J. R., Gitelman, D. R., Parrish, T. B., & Mesulam, M. (2002). Modality independence of word comprehension....
  • Brainmap.org. https://www.brainmap.org/. Accessed 10/12/2015
  • Brodmann’s Interactive Atlas. http://www.fmriconsulting.com/brodmann/BA5.html. Accessed 10/12/2014
  • Chayer, C., & Freedman, M. (2001). Frontal lobe functions. Current Neurology and Neuroscience Reports, 1, 547-552 .
  • Collins, M. L. (2001). Handbook of developmental cognitive neuroscience. Cambridge: MIT Press.
  • Cummings, J. L. (1993). Frontal-subcortical circuits and human behavior. Archives of Neurology, 50, 873-880.
  • Damasio, A., & Anderson, S. W. (2003). The frontal lobes. In K. M. Heilman & E. Valenstein (Eds.), Clinical Neuropsychology (4th ed.,...
  • Damasio, H., Grabowski, T. J., Tranel, D., Ponto, L. L., Hichwa, R. D., & Damasio, A. R. (2001). Neural correlates of naming actions and...
  • Davis, M. H., Meunier, F., & Marslen-Wilson, W. D. (2004). Neural responses to morphological, syntactic, and semantic properties of single...
  • Dapretto, M., & Bookheimer, S. Y. (1999). Form and content: Dissociating syntax and semantics in sentence comprehension. Neuron, 24(2),...
  • De Carli, D., Garreffa, G., Colonnese, C., Giulietti, G., Labruna, L., Briselli, E., Ken, S., Macrì, M.A., & Maraviglia, B. (2007). Identification...
  • Desai, R., Conant, L. L., Waldron, E., & Binder, J. R. (2006). FMRI of past tense processing: The effects of phonological complexity and...
  • Devlin, J., Matthews, P., & Rushworth, M. (2003). Semantic processing in the left inferior prefrontal cortex: A combined functional magnetic...
  • Duffau, H., Gatignol, P., Moritz-Gasser, S., & Mandonnet, E. (2009). Is the left uncinate fasciculus essential for language? Journal of...
  • Fox, P. T., Ingham, R. J., Ingham, J. C., Zamarripa, F., Xiong, J. H., & Lancaster, J. L. (2000). Brain correlates of stuttering and syllable...
  • Fuster, J. M. (2001). The prefrontal cortex-an update: Time is of the essence. Neuron, 30, 319-333.
  • Fuster, J. M. ( 2002). Frontal lobe and cognitive development . Journal of Neuropsychology, 31, 373-385.
  • Fuster, J. M. (2008). The prefrontal cortex (4th ed.). Boston: Academic Press.
  • Goldberg, E. (2001). The executive brain. New York: Oxford University Press.
  • Grafman, J. (2006). Human prefrontal cortex: Processes and representations. In J. Risberg & J. Grafman (Eds.), The frontal lobes: Development,...
  • Grodzinsky, Y., & Amunts, K. (Eds.) (2006). Broca’s region. New York: Oxford University Press.
  • Jackson III, O., & Schacter, D. L. (2004). Encoding activity in anterior medial temporal lobe supports subsequent associative recognition....
  • Jurado, M. B., & Rosselli, M. (2007). The elusive nature of executive functions: A review of our current understanding. Neuropsychology...
  • Heim, S., Opitz, B., Müller, K., & Friederici, A. D. (2003). Phonological processing during language production: fMRI evidence for a shared...
  • Hickok, G., & Poeppel, D. (2004). Dorsal and ventral streams: A framework for understanding aspects of the functional anatomy of language....
  • Inui, T., Otsu, Y., Tanaka, S., Okada, T., Nishizawa, S., & Konishi, J. (1998). A functional MRI analysis of comprehension processes of...
  • Jackson, O., & Schacter, D. L. (2004). Encoding activity in anterior medial temporal lobe supports subsequent associative recognition....
  • Kang, A. M., Constable, R. T., Gore, J. C., & Avrutin, S. (1999). An eventrelated fMRI study of implicit phrase-level syntactic and semantic...
  • Koziol, L. F., & Budding, D. E. (2009). Subcortical structures and cognition. New York: Springer.
  • Laird, A. R., Fox, P. M., Price, C. J., Glahn, D. C., Uecker, A. M., Lancaster, J. L.,Turkeltaub, P. E., Kochunov, P., & Fox, P. T. (2005)....
  • Longe, O., Randall, B., Stamatakis, E. A., & Tyler, L. (2007). Grammatical categories in the brain: The role of morphological structure....
  • Luria, A. R. (1980). Higher cortical functions in man (2nd ed.). New York: Basic
  • Mandonnet, E., Nouet, A., Gatignol, P., Capelle, L., & Duffau, H. (2007). Does the left inferior longitudinal fasciculus play a role in...
  • Martino, J., Brogna, C., Robles, S. G., Vergani, F., & Duffau, H. (2010). Anatomic dissection of the inferior fronto-occipital fasciculus...
  • McDermott, K. B., Petersen, S. E., Watson, J. M., & Ojemann, J. G. (2003). A procedure for identifying regions preferentially activated...
  • Mesulam, M. M. (1986). Frontal cortex and behavior. Annals of Neurology, 19, 320-325.
  • Mesulam, M. M. (2002). The human frontal lobes: Transcending the default mode through contingent encoding. In D. T. Stuss & R. T. Knight...
  • Peck, K. K., Wierenga, C. E., Moore, A. B., Maher, L. M., Gopinath, K., Gaiefsky, M., ... & Crosson, B. (2004). Comparison of baseline...
  • Poldrack, R., Temple, E., Protopapas, A., Nagarajan, S., Tallal, P., Merzenich, M., & Gabrieli, J. (2001). Relations between the neural...
  • Price, C. J., Green, D. W., & Von Studnitz, R. (1999). A functional imaging study of translation and language switching. Brain, 122(12),...
  • Robinson, J. L., Laird, A. R., Glahn, D. C., Lovallo, W. R., & Fox, P. T. (2010). Meta-analytic connectivity modeling: Delineating the...
  • Ross, E. D. (1981). The aprosodias: Functional-anatomical organization of the affective components of language in the right hemisphere. Archives...
  • Rosen, H. J., Petersen, S. E., Linenweber, M. R., Snyder, A. Z., White, D. A., Chapman, L., & Corbetta, M. (2000). Neural correlates of...
  • Rowan, A., Liégeois, F., Vargha-Khadem, F., Gadian, D., Connelly, A., & Baldeweg, T. (2004). Cortical lateralization during verb generation:...
  • Sabsevitz, D. S., Medler, D. A., Seidenberg, M., & Binder, J. R. (2005). Modulation of the semantic system by word imageability. Neuroimage,...
  • Schlösser, R., Hutchinson, M., Joseffer, S., Rusinek, H., Saarimaki, A., Stevenson, J., Dewey, S. L., & Brodie, J. D. (1998). Functional...
  • Shammi, P., & Stuss, D. T. (1999). Humour appreciation: A role of the right frontal lobe. Brain, 122(4), 657-666.
  • Sharp, D. J., Awad, M., Warren, J. E., Wise, R. J., Vigliocco, G., & Scott, S. K. (2010). The neural response to changing semantic and...
  • Shuster, L. I., & Lemieux, S. K. (2005). An fMRI investigation of covertly and overtly produced mono-and multisyllabic words. Brain and...
  • Simmons, W. K., Hamann, S. B., Harenski, C. L., Hu, X. P., & Barsalou, L. W. (2008). fMRI evidence for word association and situated simulation...
  • Stuss, D. T., & Alexander, M. P. (2000). Executive functions and the frontal lobe: A conceptual view. Psychological Research, 63, 289-298.
  • Stuss, D. T., & Alexander, M. P. (2007). Is there a dysexecutive syndrome? Philosophical Transactions of the Royal Society, 362, 901-915.
  • Stuss, D. T., & Knight, R. T. (2002). Principles of frontal lobe function. New York: Oxford University Press.
  • Tan, L. H., Spinks, J. A., Feng, C. M., Siok, W. T., Perfetti, C. A., Xiong, J., & Gao, J. H. (2003). Neural systems of second language...
  • Tonkonogy, J., & Puente, A. (2009). Localization of clinical syndromes in neuropsychology and neuroscience. New York: Springer Publishing...
  • Turkeltaub, P. E., Eden, G. F., Jones, K. M., & Zeffi ro, T. A. (2002). Metaanalysis of the functional neuroanatomy of single-word reading:...
  • Turken, U., & Dronkers, N. F. (2011). The neural architecture of the language comprehension network: Converging evidence from lesion and...
  • Wang, S., Zhu, Z., Zhang, J. X., Wang, Z., Xiao, Z., Xiang, H., & Chen, H. C. (2008). Broca’s area plays a role in syntactic processing...
  • Wernicke, C. (1874). Der Aphasiche Symptomencomplex. Breslau: Cohn & Weigert.