An expert Delphi consensus for the characteristics of an ideal clozapine-specific side effect scale

• Emilio Fernandez-Egea ^[1] ; Miquel Bernardo ^[2]
  1. [1] University of Cambridge

     University of Cambridge

     Cambridge District, Reino Unido

     
  2. [2] Universitat de Barcelona

     Universitat de Barcelona

     Barcelona, España

     
• Localización: European journal of psychiatry, ISSN 0213-6163, Vol. 38, Nº 4, 2024
• Idioma: inglés
• DOI: 10.1016/j.ejpsy.2024.100267
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• Resumen

  • This study employed the Delphi method to identify the ideal characteristics of a clozapine adverse drug reaction (ADR) scale, engaging 34 clozapine specialists at the 6th NEMEA meeting. Participants emphasized the integration of clinician-rated (CROM) and patient-rated (PROM) outcomes in the scale, aiming for a balance between comprehensiveness and practical- ity. Key consensus points included the inclusion of specific ADRs like somnolence, sialorrhea, and compulsivity, while metabolic complications were considered less relevant. This research high- lights the need for a practical, patient-inclusive tool for monitoring clozapine ADRs, reflective of both clinical expertise and patient experiences in managing treatment-resistant schizophrenia