Gender differences in the therapeutic response to lifestyle improvement-based interventions for treatment-resistant depression

• Alejandra Aguilar-Latorre ^[2] ; Margalida Gili ^[3] ; Capilla Navarro-Guzmán ^[1] ; Aurora Garcia ^[4] ; Aina M. Yáñez ^[5] ; Mauro Garcia-Toro ^[6]
  1. [1] Universitat de les Illes Balears

     Universitat de les Illes Balears

     Palma de Mallorca, España

     
  2. [2] Institute for Health Research Aragón (IIS Aragón), Zaragoza, Spain; Research Network on Chronicity, Primary Care and Health Promotion (RICAPPS), Carlos III Health Institute, Madrid, Spain; Department of Psychology and Sociology, University of Zaragoza, Huesca, Spain
  3. [3] Research Network on Chronicity, Primary Care and Health Promotion (RICAPPS), Carlos III Health Institute, Madrid, Spain; Department of Psychology, University of the Balearic Islands, Palma, Balearic Islands, Spain; University Institute of Health Science Research (IUNICS), University of the Balearic Islands, Palma, Spain
  4. [4] University Institute of Health Science Research (IUNICS), University of the Balearic Islands, Palma, Spain
  5. [5] Research Network on Chronicity, Primary Care and Health Promotion (RICAPPS), Carlos III Health Institute, Madrid, Spain; University Institute of Health Science Research (IUNICS), University of the Balearic Islands, Palma, Spain; Department of Nursing and Physiotherapy, University of the Balearic Islands, Palma, Balearic Islands, Spain; Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain
  6. [6] Research Network on Chronicity, Primary Care and Health Promotion (RICAPPS), Carlos III Health Institute, Madrid, Spain; University Institute of Health Science Research (IUNICS), University of the Balearic Islands, Palma, Spain; Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain; Department of Medicine, University of the Balearic Islands, Palma, Spain

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• Localización: European journal of psychiatry, ISSN 0213-6163, Vol. 38, Nº 3, 2024
• Idioma: inglés
• DOI: 10.1016/j.ejpsy.2024.100254
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• Resumen

  • Treatment-resistant depression (TRD) poses a significant societal challenge, with gender-specific treatment gaps. In a clinical trial targeting TRD, we introduced lifestyle-based interventions. Analyzing data from 24 men and 70 women with TRD, the current study aimed to assess gender-related efficacy differences. Descriptive and univariate analyses unveiled variations in sociodemographic and clinical factors. Utilizing repeated measures ANOVA while controlling for baseline values and age, results indicated a notable gender disparity. Specifically, women exhibited a significantly poorer progression of depressive symptoms. This underscores the need for tailored interventions addressing gender-specific nuances in TRD treatment.