Basal forebrain modulation of olfactory coding in vivo

• Juan Pablo Venegas ^[1] ; Marcela Navarrete ^[1] ; Laura Orellana Garcia ^[1] ; Marcelo Rojas ^[1] ; Felipe Avello Duarte ^[1] ; Alexia Nunez Parra ^[1]
  1. [1] Universidad de Chile

     Universidad de Chile

     Santiago, Chile

     
• Localización: International Journal of Psychological Research, ISSN 2011-2084, ISSN-e 2011-2084, Vol. 16, Nº. 2, 2023, págs. 62-86
• Idioma: inglés
• DOI: 10.21500/20112084.6486
• Títulos paralelos:
  • Modulación del cerebro basal en la codificación olfatoriain vivo
• Enlaces
  • Texto completo (pdf)
• Resumen
  • español

    La percepción sensorial es una de las funciones cerebrales más fundamentales, permitiendo a los individuos interactuar de manera apropiada con el entorno y adaptarse a un ambiente en constante cambio. Este proceso re-quiere la integración de la actividad neuronal ascendente y descendente, que es mediada por el cerebro basal (BF), una región cerebral que ha sido asociada a una serie de procesos cognitivos, como estados de atención y alerta. En este trabajo revisamos las últimas investigaciones que han utilizado optogenética y registros electrofisiológicos in vivo que han iluminado el rol del BF en el procesamiento olfatorio y la toma de decisiones .Además, resumimos la literatura que destaca las alteraciones fisiológicas y anatómicas del BF de individuos con trastornos del espectro autista, que podrían subyacer las anormalidades en la percepción que presentan, y proponemos esta línea de investigación como una posible oportunidad para entender las bases neurobiológicas de este trastorno.

  • English

    Sensory perception is one of the most fundamental brain functions allowing individuals to properly interact and adapt to a constantly changing environment. This process requires the integration of bottom-up and top-down neuronal activity that is centrally mediated by the basal forebrain, a brain region that has been linked to a series of cognitive processes such as attention and alertness. Here, we review the latest research using optogenetic approaches in rodents and in vivo electrophysiological recordings that are shedding light into the role of this region regulating olfactory processing and decision-making. Moreover, we summarize evidence highlighting the anatomical and physiological differences in the basal forebrain of individuals with autism spectrum disorder, which could underpin the sensory perception abnormalities they exhibit and propose this research line as a potential opportunity to understand the neurobiological basis of this disorder.

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