Neurophysiological markers of disease severity and cognitive dysfunction in major depressive disorder: a TMS-EEG study

• Deyang Li ^[1] ; Xingxing Li ^[1] ; Jiaxin Li ^[1] ; Junyao Liu ^[1] ; Ruichenxi Luo ^[1] ; Yanli Li ^[1] ; Dongmei Wang ^[1] ; Dongsheng Zhou ^[2] ; Xiang-Yang Zhang ^[1]
  1. [1] Chinese Academy of Sciences

     Chinese Academy of Sciences

     China

     
  2. [2] Ningbo University

     Ningbo University

     China

     
• Localización: International journal of clinical and health psychology, ISSN 1697-2600, Vol. 24, Nº. 3, 2024, págs. 211-220
• Idioma: inglés
• DOI: 10.1016/j.ijchp.2024.100495
• Enlaces
  • Texto completo
• Resumen

  • Background Transcranial magnetic stimulation-electroencephalography (TMS-EEG) is a powerful technique to study the neuropathology and biomarkers of major depressive disorder (MDD). This study investigated cortical activity and its relationship with clinical symptoms and cognitive dysfunction in MDD patients by indexing TMS-EEG biomarkers in the dorsolateral prefrontal cortex (DLPFC).

    Methods 133 patients with MDD and 76 healthy individuals participated in this study. Single-pulse TMS was performed on the left DLPFC to obtain TMS-evoked potential (TEP) indices. TMS-EEG waveforms and components were determined by global mean field amplitude. We used the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) to measure participants’ cognitive function.

    Results Patients with MDD had a lower excitatory P180 index compared to healthy controls, and P180 amplitude was negatively correlated with the severity of depressive and anxiety symptoms in patients with MDD. In the MDD group, P30 amplitude was negatively associated with RBANS Visuospatial/ Constructional index and total score.

    Conclusions TMS-EEG findings suggest that abnormal cortical excitation and inhibition induced by TMS on the DLPFC are associated with the severity of clinical symptoms and cognitive dysfunction in patients with MDD. P180 and P30 have the potential to serve as neurophysiological biomarkers of clinical symptoms and cognitive dysfunction in MDD patients, respectively.

• Referencias bibliográficas
  • Bagattini, C., Mutanen, T. P., Fracassi, C., Manenti, R., Cotelli, M., Ilmoniemi, R. J., et al. (2019). Predicting Alzheimer’s disease severity...
  • Belardinelli, P., Konig, F., Liang, C., Premoli, I., Desideri, D., Müller-Dahlhaus, F., et al. (2021). TMS-EEG signatures of glutamatergic...
  • Biermann, L., Wunram, H. L., Pokorny, L., Breitinger, E., Grossheinrich, N., Jarczok, T. A., et al. (2022). Changes in the TMS-evoked potential...
  • Burke, M. J., Romanella, S. M., Mencarelli, L., Greben, R., Fox, M. D., Kaptchuk, T. J., et al. (2022). Placebo effects and neuromodulation...
  • Casarotto, S., Maatta, S., Herukka, S. K., Pigorini, A., Napolitani, M., Gosseries, O., et al. (2011). Transcranial magnetic stimulation-evoked...
  • Chen, L. J., Wang, Q., & Xu, T. C. (2023). Working memory function in patients with major depression disorder: A narrative review. Clinical...
  • Conde, V., Tomasevic, L., Akopian, I., Stanek, K., Saturnino, G. B., Thielscher, A., et al. (2019). The non-transcranial TMS-evoked potential...
  • Darmani, G., Bergmann, T. O., Zipser, C., Baur, D., Müller-Dahlhaus, F., & Ziemann, U. (2019). Effects of antiepileptic drugs on cortical...
  • Delorme, A., & Makeig, S. (2004). EEGLAB: An open source toolbox for analysis of single- trial EEG dynamics including independent component...
  • Dhami, P., Atluri, S., Lee, J. C., Knyahnytska, Y., Croarkin, P. E., Blumberger, D. M., et al. (2020). Prefrontal cortical reactivity and...
  • Dhami, P., Moreno, S., Croarkin, P. E., Blumberger, D. M., Daskalakis, Z. J., & Farzan, F. (2023). Baseline markers of cortical excitation...
  • Di Lazzaro, V., Bella, R., Benussi, A., Bologna, M., Borroni, B., Capone, F., et al. (2021). Diagnostic contribution and therapeutic perspectives...
  • Eleonora, M., Giuseppe, D., Marika, G., Marco, G., Sara, P., Carolina, B., et al. (2019). Common and different neural markers in major depression...
  • Farzan, F. (2023). Transcranial magnetic stimulation-electroencephalography for biomarker discovery in psychiatry. Biological Psychiatry,...
  • Farzan, F., Barr, M. S., Hoppenbrouwers, S. S., Fitzgerald, P. B., Chen, R., Pascual- Leone, A., et al. (2013). The EEG correlates of the...
  • Ferrarelli, F., & Phillips, M. L. (2021). Examining and modulating neural circuits in psychiatric disorders with transcranial magnetic...
  • Ferreri, F., Pasqualetti, P., Maatta, S., Ponzo, D., Ferrarelli, F., Tononi, G., et al. (2011). Human brain connectivity during single and...
  • Fossati, P. (2018). Is major depression a cognitive disorder? Revue Neurologique, 174(4), 212–215. https://doi.org/10.1016/j.neurol.2018.01.365
  • Gefferie, S. R., Jimenez-Jimenez, D., Visser, G. H., Helling, R. M., Sander, J. W., Balestrini, S., et al. (2023). Transcranial magnetic stimulation-evoked...
  • Hadas, I., Zomorrodi, R., Hill, A. T., Sun, Y. M., Fitzgerald, P. B., Blumberger, D. M., et al. (2020). Subgenual cingulate connectivity and...
  • Hamilton, M. (1959). The assessment of anxiety states by rating. The British Journal of Medical Psychology, 32(1), 50–55. https://doi.org/10.1111/j.2044-8341.1959....
  • Hasler, G., Neumeister, A., van der Veen, J. W., Tumonis, T., Bain, E. E., Shen, J., et al. (2005). Normal prefrontal gamma-aminobutyric acid...
  • Husain, M., & Nachev, P. (2007). Space and the parietal cortex. Trends in Cognitive Sciences, 11(1), 30–36. https://doi.org/10.1016/j.tics.2006.10.011
  • Jacob, T. C. (2019). Neurobiology and therapeutic potential of α5-GABA type A receptors. Frontiers in Molecular Neuroscience, 12, 179. https://doi.org/10.3389/...
  • Joseph, S., Knezevic, D., Zomorrodi, R., Blumberger, D. M., Daskalakis, Z. J., Mulsant, B. H., et al. (2021). Dorsolateral prefrontal cortex...
  • Kallioniemi, E., & Daskalakis, Z. J. (2022). Identifying novel biomarkers with TMS-EEG - Methodological possibilities and challenges....
  • Kallioniemi, E., Saari, J., Ferreri, F., & Maatta, S. (2022). TMS-EEG responses across the lifespan: Measurement, methods for characterisation...
  • Kamishikiryo, T., Okada, G., Itai, E., Masuda, Y., Yokoyama, S., Takamura, M., et al. (2022). Left DLPFC activity is associated with plasma...
  • Kantrowitz, J. T., Dong, Z. C., Milak, M. S., Rashid, R., Kegeles, L. S., Javitt, D. C., et al. (2021). Ventromedial prefrontal cortex/anterior...
  • Koh, M. T., Branch, A., Haberman, R., & Gallagher, M. (2020). Significance of inhibitory recruitment in aging with preserved cognition:...
  • Kriesche, D., Woll, C. F. J., Tschentscher, N., Engel, R. R., & Karch, S. (2023). Neurocognitive deficits in depression: A systematic...
  • Lehmann, D., & Skrandies, W. (1980). Reference-free identification of components of checkerboard-evoked multichannel potential fields....
  • Li, X. X., Chen, M., Liu, Q. Q., Zheng, C., Yu, C., Hou, G. W., et al. (2023). TMS-evoked potential in the dorsolateral prefrontal cortex...
  • Luscher, B., Maguire, J. L., Rudolph, U., & Sibille, E. (2023). GABAA receptors as targets for treating affective and cognitive symptoms...
  • Moriguchi, S., Takamiya, A., Noda, Y., Horita, N., Wada, M., Tsugawa, S., et al. (2019). Glutamatergic neurometabolite levels in major depressive...
  • Morozova, A., Zorkina, Y., Abramova, O., Pavlova, O., Pavlov, K., Soloveva, K., et al. (2022). Neurobiological highlights of cognitive impairment...
  • Oostenveld, R., Fries, P., Maris, E., & Schoffelen, J. M. (2011). FieldTrip: Open source software for advanced analysis of MEG, EEG, and...
  • Pievani, M., Filippini, N., van den Heuvel, M. P., Cappa, S. F., & Frisoni, G. B. (2014). Brain connectivity in neurodegenerative diseases-from...
  • Pilisi, R., Tenyi, T., Büki, A., Kovacs, N., Zemplenyi, A., Sebestyen, G., et al. (2020). The role of repetitive transcranial magnetic stimulation...
  • Poorganji, M., Zomorrodi, R., Hawco, C., Hill, A. T., Hadas, I., Zrenner, C., et al. (2023). Isolating sensory artifacts in the suprathreshold...
  • Premoli, I., Bergmann, T. O., Fecchio, M., Rosanova, M., Biondi, A., Belardinelli, P., et al. (2017a). The impact of GABAergic drugs on TMS-induced...
  • Premoli, I., Castellanos, N., Rivolta, D., Belardinelli, P., Bajo, R., Zipser, C., et al. (2014a). TMS- EEG signatures of GABAergic neurotransmission...
  • Premoli, I., Costantini, A., Rivolta, D., Biondi, A., & Richardson, M. P. (2017b). The effect of lamotrigine and levetiracetam on TMS-evoked...
  • Premoli, I., Rivolta, D., Espenhahn, S., Castellanos, N., Belardinelli, P., Ziemann, U., et al. (2014b). Characterization of GABAB-receptor...
  • Randolph, C., Tierney, M. C., Mohr, E., & Chase, T. N. (1998). The repeatable battery for the assessment of neuropsychological status...
  • Redondo-Camos, M., Cattaneo, G., Perellon-Alfonso, R., Alviarez-Schulze, V., Morris, T. P., Solana-Sanchez, J., et al. (2022). Local prefrontal...
  • Rogasch, N. C., Daskalakis, Z. J., & Fitzgerald, P. B. (2015). Cortical inhibition of distinct mechanisms in the dorsolateral prefrontal...
  • Rogasch, N. C., Sullivan, C., Thomson, R. H., Rose, N. S., Bailey, N. W., Fitzgerald, P. B., et al. (2017). Analysing concurrent transcranial...
  • Rogasch, N. C., Thomson, R. H., Daskalakis, Z. J., & Fitzgerald, P. B. (2013). Short- latency artifacts associated with concurrent TMS-EEG....
  • Rogasch, N. C., Zipser, C., Darmani, G., Mutanen, T. P., Biabani, M., Zrenner, C., et al. (2020). The effects of NMDA receptor blockade on...
  • Schwab, J. J., Bialow, M. R., Clemmons, R. S., & Holzer, C. E. (1967). Hamilton rating scale for depression with medical in-patients....
  • Shen, T., Li, C., Wang, B., Yang, W. M., Zhang, C., Wu, Z. G., et al. (2015). Increased cognition connectivity network in major depression...
  • Strafella, R., Momi, D., Zomorrodi, R., Lissemore, J., Noda, Y., Chen, R., et al. (2023). Identifying neurophysiological markers of intermittent...
  • Subhas, N., Ang, J. K., Tan, K. A., & Ahmad, S. N. A. (2023). Relations between clinical characteristics and cognitive deficits among...
  • ter Braack, E. M., de Vos, C. C., & van Putten, M. (2015). Masking the auditory evoked potential in TMS-EEG: A comparison of various methods....
  • Tran, K. H., Luki, J., Hanstock, S., Hanstock, C. C., Seres, P., Aitchison, K., et al. (2023). Decreased GABA plus ratios referenced to creatine...
  • Voineskos, D., Blumberger, D. M., Rogasch, N. C., Zomorrodi, R., Farzan, F., Foussias, G., et al. (2021). Neurophysiological effects of repetitive...
  • Voineskos, D., Blumberger, D. M., Zomorrodi, R., Rogasch, N. C., Farzan, F., Foussias, G., et al. (2019). Altered transcranial magnetic stimulation-electroencephalographic...
  • White, L. K., Makhoul, W., Teferi, M., Sheline, Y. I., & Balderston, N. L. (2023). The role of dlPFC laterality in the expression and...
  • World Health Organization. (2023). World Health Organization fact sheet of depressive disorder. Retrieved December 11 2023 from https://www.who.int/news-room/fact-sheets/detail/depression.
  • Yosephi, M. H., Ehsani, F., Daghiani, M., Zoghi, M., & Jaberzadeh, S. (2019). The effects of trans-cranial direct current stimulation...
  • Zhang, B. H., Tan, Y. L., Zhang, W. F., Wang, Z., Yang, R., G, G., et al. (2008). Repeatable battery for the assessment of neuropsychologicar...
  • Zhang, L. L., Cui, X. L., Ou, Y. P., Liu, F., Li, H. B., Xie, G. J., et al. (2023). Abnormal long- and short-range functional connectivity...
  • Zhang, X. M., Zhang, R. R., Lv, L. L., Qi, X. Y., Shi, J. P., & Xie, S. P. (2022). Correlation between cognitive deficits and dorsolateral...