Hypoconnectivity networks in schizophrenia patients: a voxel-wise meta-analysis of Rs-fMRI

• Silvia Ruiz-Torras ^[1] ; Esteve Gudayol-Ferré ^[2] ; Oscar Fernández-Vazquez ^[1] ; Cristina Cañete-Massé ^[1] ; Maribel Peró-Cebollero ^[1] ; Joan Guàrdia-Olmos ^[1]
  1. [1] Universitat de Barcelona

     Universitat de Barcelona

     Barcelona, España

     
  2. [2] Universidad Michoacana San Nicolás de Hidalgo, Mexico
• Localización: International journal of clinical and health psychology, ISSN 1697-2600, Vol. 23, Nº. 4, 2023, págs. 201-210
• Idioma: inglés
• DOI: 10.1016/j.ijchp.2023.100395
• Enlaces
  • Texto completo (pdf)
• Resumen

  • Background In recent years several meta-analyses regarding resting-state functional connectivity in patients with schizophrenia have been published. The authors have used different data analysis techniques: regional homogeneity, seed-based data analysis, independent component analysis, and amplitude of low frequencies. Hence, we aim to perform a meta-analysis to identify connectivity networks with different activation patterns between people diagnosed with schizophrenia and healthy controls using voxel-wise analysis. Method: We collected primary studies exploring whole brain connectivity by functional magnetic resonance imaging at rest in patients with schizophrenia compared with healthy controls. We identified 25 studies included high-quality studies that included 1285 patients with schizophrenia and 1279 healthy controls. Results: The results indicate hypoactivation in the right precentral gyrus and the left superior temporal gyrus of patients with schizophrenia compared with healthy controls. Conclusions: These regions have been linked with some clinical symptoms usually present in Plea with schizophrenia, such as auditory verbal hallucinations, formal thought disorder, and the comprehension and production of gestures.

• Referencias bibliográficas
  • Albajes-Eizagirre, A., Solanes, A., Vieta, E., Salvador, R., Pomarol, E., & Radua, J. (2021). Voxel-based meta-analysis via permutation...
  • Alderson-Day, B., Diederen, K., Fernyhough, C., Ford, J. M., Horga, G., Margulies, D. S., … Jardri, R. (2016). Auditory hallucinations and...
  • Alonso-Solís, A., Vives-Gilabert, Y., Portella, M. J., Rabella, M., Grasa, E. M., Rolda´n, A., Keymer-Gausset, A., Molins, C., Nún˜ez-Marín,...
  • Andric, M., & Small, S. L. (2012). Gesture’s neural language. Frontiers in psychology, 3, 99. https://doi.org/10.3389/fpsyg.2012.00099
  • Bai, Y., Wang, W., Xu, J., Zhang, F., Yu, H., Luo, C., Wang, L., Chen, X., Shan, B., Xu, L., Xu, X., & Cheng, Y. (2016). Altered resting-state...
  • Bluhm, R. L., Miller, J., Lanius, R. A., Osuch, E. A., Boksman, K., Neufeld, R. W. J., … Williamson, P. (2007). Spontaneous low-frequency...
  • Cavelti, M., Kircher, T., Nagels, A., Strik, W., & Homan, P. (2018). Is formal thought disorder in schizophrenia related to structural...
  • Cañete, C., Carbo, M., Pero´, M., & Guardia, J. (2021). Task-related brain activation fMRI in intellectual disability population: A metanalytic...
  • Chen, Z. Q., Du, M. Y., Zhao, Y. J., Huang, X. Q., Li, J., Lui, S., Hu, J., Sun, H., Liu, J., Kemp, G. J., & Gong, Q. Y (2015). Voxel-wise...
  • Ding, Y., Ou, Y., Su, Q., Pan, P., Shan, X., Chen, J., Liu, F., Zhang, Z., Zhao, J., & Guo, W. (2019). Enhanced global-brain functional...
  • Dong, D., Wang, Y., Chang, X., Luo, C., & Yao, D. (2018). Dysfunction of large-scale brain networks in schizophrenia: a meta-analysis...
  • Fryer, S. L., Roach, B. J., Ford, J. M., Turner, J. A., Van Erp, T. G., Voyvodic, J., Preda, A., Belger, A., Bustillo, J., O’Leary, D., Mueller,...
  • Friederici, A. D., & Gierhan, S. M. (2013). The language network. Current Opinion in Neurobiology, 23(2), 250–254. https://doi.org/10.1016/j.conb.2012.10.002
  • Friston, K. J., & Frith, C. D. (1995). Schizophrenia: A disconnection syndrome. Clinical Neuroscience, 3(2), 89–97.
  • Forlim, C. G., Klock, L., Bachle, J., Stoll, L., Giemsa, P., Fuchs, M., Shoofs, N., Montag, C., Gallinat, J., & Kühn, S. (2020). Reduced...
  • Fornito, A., Yoon, J., Zalesky, A., Bullmore, E. T., & Carter, C. S. (2011). General and specific functional connectivity disturbances...
  • Gao, B., Wang, Y., Liu, W., Chen, Z., Zhou, H., Yang, J., Cohen, Z., Zhu, Y., & Zang, Y. (2015). Spontaneous activity associated with...
  • Gao, S., Lu, S., Shi, X., Ming, Y., Xiao, C., Sun, J., Yao, H., & Xu, X. (2018). Distinguishing between treatment-resistant and non-treatment-resistant...
  • Geoffroy, P. A., Houenou, J., Duhamel, A., Amad, A., De Weijer, A. D., Curcic-Blake, B., … Jardri, R. (2014). The arcuate fasciculus in auditory-verbal...
  • Gong, J., Wang, J., Luo, X., Chen, G., Huang, H., Huang, R., Huang, L., & Wang, Y. (2020). Abnormalities of intrinsic regional brain activity...
  • Gou, N., Liu, Z., Palaniyappan, L., Li, M., Pan, Y., Chen, X., Tao, H., Wu, G., Ouyang, X., Wang, Z., Dou, T., Xue, Z., & Pu, W. (2018)....
  • Guo, W., Liu, F., Chen, J., Wu, R., Li, L., Zhang, Z., Chen, H., & Zhao, J. (2017). Treatment effects of olanzapine on homotopic connectivity...
  • Guo, W., Liu, F., Chen, J., Wu, R., Li, L., Zhang, Z., & Zhao, J. (2016). Olanzapine modulation of long-and short-range functional connectivity...
  • Guo, W., Liu, F., Xiao, C., Liu, J., Yu, M., Zhang, Z., Zhang, J., & Zhao, J. (2015). Increased short-range and long-range functional...
  • He, Z., Deng, W., Li, M., Chen, Z., Jiang, L., Wang, Q., … Li, T. (2013). Aberrant intrinsic brain activity and cognitive deficit in first-episode...
  • Horne, C. M., Vanes, L. D., Verneuil, T., Mouchlianitis, E., Szentgyorgyi, T., Averbeck, B., … Shergill, S. S. (2021). Cognitive control network...
  • Huang, H., Botao, Z., Jiang, Y., Tang, Y., Zhang, T., Tang, X., & Wang, J. (2019). Aberrant resting-state functional connectivity of salience...
  • Kasai, K., Shenton, M. E., Salisbury, D. F., Hirayasu, Y., Lee, C. U., Ciszewski, A. A., … McCarley, R. W. (2003). Progressive decrease of...
  • Kircher, T. T., Liddle, P. F., Brammer, M. J., Williams, S. C., Murray, R. M., & McGuire, P. K. (2001). Neural correlates of formal thought...
  • Kircher, T. T., Liddle, P. F., Brammer, M. J., Williams, S. C. R., Murray, R. M., & McGuire, P. K. (2002). Reversed lateralization of...
  • Kühn, S., & Gallinat, J. (2013). Resting-state brain activity in schizophrenia and major depression: a quantitative meta-analysis. Schizophrenia...
  • Larivi`ere, S., Lavigne, K. M., Woodward, T. S., Gerretsen, P., Graff-Guerrero, A., & Menon, M. (2017). Altered functional connectivity...
  • Li, H., Ou, Y., Liu, F., Chen, J., Zhao, J., Guo, W., & Fan, X. (2019). Reduced connectivity in anterior cingulate cortex as an early...
  • Li, S., Hu, N., Zhang, W., Tao, B., Dai, J., Gong, Y., Tan, Y., Cai, D., & Lui, S. (2019). Dysconnectivity of multiple brain networks...
  • Li, Z., Lei, W., Deng, W., Zheng, Z., Li, M., Ma, X., Wang, Q., Huang, X., Li, N., Collier, D. A., Gong, Q., & Li, T. (2017). Aberrant...
  • Liang, Y., Shao, R., Zhang, Z., Li, X., Zhou, L., & Guo, S. (2019). Amplitude of low- frequency fluctuations in childhood-onset schizophrenia...
  • Liao, W., Yang, S., Li, J., Fan, Y. S., Duan, X., Cui, Q., & Chen, H. (2019). Nicotine in action: Cigarette smoking modulated homotopic...
  • Liu, C., Xue, Z., Palaniyappan, L., Zhou, L., Liu, H., Qi, C., Wu, G., Mwansisya, T. E., Tao, H., Chen, X., Huang, X., Liu, Z., & Pu,...
  • Liu, H., Liu, Z., Liang, M., Hao, Y., Tan, L., Kuang, F., Yi, Y., Xu, L., & Jiang, T. (2006). Decreased regional homogeneity in schizophrenia:...
  • Liu, Y., Zhang, Y., Lv, L., Wu, R., Zhao, J., & Guo, W. (2017). Abnormal neural activity as a potential biomarker for drug-naive first-episode...
  • Menon, V., Palaniyappan, L., & Supekar, K. (2022). Integrative brain network and salience models of psychopathology and cognitive dysfunction...
  • Moran, L. V., Tagamets, M. A., Sampath, H., O’Donnell, A., Stein, E. A., Kochunov, P., & Hong, L. E. (2013). Disruption of anterior insula...
  • Müller, V. I., Cieslik, E. C., Laird, A. R., Fox, P. T., Radua, J., Mataix-Cols, D., & Eickhoff, S. B. (2018). Ten simple rules for neuroimaging...
  • Mwansisya, T. E., Hu, A., Li, Y., Chen, X., Wu, G., Huang, X., & Liu, Z. (2017). Task and resting-state fMRI studies in first-episode...
  • Nagels, A., Kircher, T., Grosvald, M., Steines, M., & Straube, B. (2019). Evidence for gesture-speech mismatch detection impairments in...
  • Owen, M. J., Sawa, A., & Mortensen, P. B. (2016). Schizophrenia. The Lancet, 388, 86–97. https://doi.org/10.1016/s0140-6736(15)01121-6
  • Palaniyappan, L., & Liddle, P. F. (2012). Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular...
  • Plaze, M., Bartr´es-Faz, D., Martinot, J. L., Januel, D., Bellivier, F., De Beaurepaire, R., … Paill`ere-Martinot, M. L. (2006). Left...
  • Radua, J., & Mataix, D. (2012). Meta-analytic methods for neuroimaging data explained. Biological Mood Anxiety Disorders, 2, 6. https://doi.org/10.1186/2045-5380-2-6
  • Ray, K. L., Lesh, T. A., Howell, A. M., Salo, T. P., Ragland, J. D., MacDonald, A. W., … Carter, C. S. (2017). Functional network changes...
  • Ren, W., Lui, S., Deng, W., Li, F., Li, M., Huang, X., Wang, Y., Li, T., Sweeney, J. A., & Gong, Q. (2013). Anatomical and functional...
  • Sommer, I. E., Clos, M., Meijering, A. L., Diederen, K. M., & Eickhoff, S. B. (2012). Resting state functional connectivity in patients...
  • Shepherd, A. M., Matheson, S. L., Laurens, K. R., & Green, M. J. (2012). Systematic meta- analysis of insula volume in schizophrenia....
  • Skudlarski, P., Jagannathan, K., Anderson, K., Stevens, M. C., Calhoun, V. D., Skudlarska, B. A., & Pearlson, G. (2010). Brain connectivity...
  • Takahashi, T., Wood, S. J., Yung, A. R., Soulsby, B., McGorry, P. D., Suzuki, M., … Pantelis, C. (2009). Progressive gray matter reduction...
  • Turner, J. A., Damaraju, E., Van Erp, T. G., Mathalon, D. H., Ford, J. M., Voyvodic, J., Mueller, B. A., Belger, A., Bustillo, J., McEwen,...
  • Van Den Heuvel, M. P., & Fornito, A (2014). Brain networks in schizophrenia. Neuropsychology Review, 24, 32–48. https://doi.org/10.1007/s11065-014-9248-7
  • Viher, P. V., Stegmayer, K., Kubicki, M., Karmacharya, S., Lyall, A. E., Federspiel, A., … Walther, S. (2018). The cortical signature of impaired...
  • Walther, S., Alexaki, D. D., Stegmayer, K. D. L., Vanbellingen, T., & Bohlhalter, S. (2020). Conceptual disorganization impairs hand gesture...
  • Walther, S., Mittal, V. A., Stegmayer, K., & Bohlhalter, S. (2020). Gesture deficits and apraxia in schizophrenia. Cortex, 133, 65–75....
  • Walther, S., Stegmayer, K., Sulzbacher, J., Vanbellingen, T., Müri, R., Strik, W., & Bohlhalter, S. (2015). Nonverbal social communication...
  • Wang, S., Zhan, Y., Zhang, Y., Lyu, L., Lyu, H., Wang, G., Wu, R., Zhao, J., & Guo, W. (2018). Abnormal long-and short-range functional...
  • Weinstein, S., Werker, J. F., Vouloumanos, A., Woodward, T. S., & Ngan, E. T. (2006). Do you hear what I hear? Neural correlates of thought...
  • Wolf, N., Gron, G., Sambataro, F., Vasic, N., Frasch, K., & Schmid, M. (2012). Magnetic resonance perfusion imaging of auditory verbal...
  • Woodruff, P. W., Wright, I. C., Bullmore, E. T., Brammer, M., Howard, R. J., Williams, S. C., … Murray, R. M. (1997). Auditory hallucinations...
  • Woodward, N. D., Rogers, B., & Heckers, S. (2011). Functional resting-state networks are differentially affected in schizophrenia. Schizophrenia...
  • Wüthrich, F., Pavlidou, A., Stegmayer, K., Eisenhardt, S., Moor, J., Sch¨appi, L., … Walther, S. (2020). Nonverbal communication remains untouched:...
  • Xia, M., Wang, J., & He, Y. (2013). BrainNet Viewer: A network visualization tool for human brain connectomics. PLoS One, 8, Article e0068910....
  • Xiao, B., Wang, S., Liu, J., Meng, T., He, Y., & Luo, X. (2017). Abnormalities of localized connectivity in schizophrenia patients and...
  • Yan, W., Zhang, R., Zhou, M., Lu, S., Li, W., Xie, S., & Zhang, N. (2020). Relationships between abnormal neural activities and cognitive...
  • Yang, J., Andric, M., & Mathew, M. M. (2015). The neural basis of hand gesture comprehension: A meta-analysis of functional magnetic resonance...
  • Yu, R., Hsieh, M. H., Wang, H. L. S., Liu, C. M., Liu, C. C., Hwang, T. J., Chien, Y. L., Hwu, H. G., & Tseng, W. Y. I. (2013). Frequency...
  • Yue, Y., Jiang, Y., Shen, T., Pi, J., Lai, H., & Zhang, B. (2020). ALFF and ReHo mapping reveals different functional patterns in early-...
  • Zhang, T., Li, C., Li, P., Peng, Y., Kang, X., Jiang, C., … Xu, P. (2020). Separated channel attention convolutional neural network (SC-CNN-attention)...
  • Zhao, X., Yao, J., Lv, Y., Zhang, X., Han, C., Chen, L., Ren, F., Jin, Z., Li, Y., & Sui, Y. (2019). Abnormalities of regional homogeneity...
  • Zheng, J., Zhang, Y., Guo, X., Duan, X., Zhang, J., Zhao, J., & Chen, H. (2016). Disrupted amplitude of low-frequency fluctuations in...
  • Zhu, F., Liu, F., Guo, W., Chen, J., Su, Q., Zhang, Z., Li, H., Fan, X., & Zhao, J. (2018). Disrupted asymmetry of inter-and intra-hemispheric...