Consideraciones clínicas, diagnósticas y de tratamiento en retinoblastoma

• Villamil Duarte, John Fredy ^[1] ; Quintero Pérez, Lina María ^[2] ; Serrano Uribe, Ronald Andrés ^[1] ; Moreno Martínez, Ivonne Andrea ^[1]
  1. [1] Médico Consultor, Bucaramanga, Colombia
  2. [2] I.P.S Coomultrasan, Bucaramanga, Colombia
• Localización: MedUNAB, ISSN-e 2382-4603, ISSN 0123-7047, Vol. 14, Nº. 3, 2011 (Ejemplar dedicado a: Nosocomial infection, Medicines price, Retinoblastoma), págs. 180-187
• Idioma: español
• DOI: 10.29375/01237047.1592
• Enlaces
  • Texto completo
• Resumen

  • El  retinoblastoma es el  tumor  intraocular  primario más frecuente en la infancia. Su detección temprana y el inicio del tratamiento adecuado permiten mejorar  dramáticamente la sobrevida en estos niños. En este artículo se hace una revisión general de la enfermedad. Se empleó PubMed y se revisaron artículos representativos del tema, que permitieran dar una idea general de los diferentes avances alcanzados. Dada su clínica característica, el médico de atención primaria, es pieza fundamental en la captación inicial del paciente.

• Referencias bibliográficas
  • Abramson DH. Retinoblastoma in the 20th century: past success and future challenges the Weisenfeld lecture. Invest Ophthalmol Vis Sci 2005;46:2683-91.
  • Shields CL, Shields JA. Diagnosis and management of retinoblastoma. Cancer Control 2004;11:317-27.
  • Broaddus E, Topham A, Singh AD. Incidence of retinoblastoma in the USA: 1975-2004. Br J Ophthalmol 2009;93:21-3.
  • Balmer A, Zografos L, Munier F. Diagnosis and current management of retinoblastoma. Oncogene 2006;25:5341-9.
  • Vasudevan V, Cheung MC, Yang R, et al. Pediatric solid tumors and second malignancies: characteristics and survival outcomes. J Surg Res 2010;160:184-9.
  • Guerin S, Hawkins M, Shamsaldin A, et al. Treatment-adjusted predisposition to second malignant neoplasms after a solid cancer in childhood:...
  • Leiderman YI, Kiss S, Mukai S. Molecular genetics of RB1--the retinoblastoma gene. Semin Ophthalmol 2007;22:247-54.
  • Godbout R, Dryja TP, Squire J, Gallie BL, Phillips RA. Somatic inactivation of genes on chromosome 13 is a common event in retinoblastoma....
  • Kato MV, Ishizaki K, Shimizu T, et al. Parental origin of germ-line and somatic mutations in the retinoblastoma gene. Hum Genet 1994;94:31-8.
  • Dryja TP, Mukai S, Petersen R, Rapaport JM, Walton D, Yandell DW. Parental origin of mutations of the retinoblastoma gene. Nature 1989;339:556-8.
  • Abramson DH, Schefler AC. Update on retinoblastoma. Retina 2004;24:828-48.
  • Poulaki V, Mukai S. Retinoblastoma: genetics and pathology. Int Ophthalmol Clin 2009;49:155-64.
  • Lueder GT, Judisch GF. Endophytic vs exophytic unilateral retinoblastoma: is there any real difference. J Pediatr Ophthalmol Strabismus 1991;28:240.
  • Longmuir SQ, Syed NA, Boldt HC. Diffuse anterior retinoblastoma without retinal involvement. Ophthalmology 2010;117:2034-8.
  • Schwimer CJ, Prayson RA. Clinicopathologic study of retinoblastoma including MIB-1, p53, and CD99 immunohistochemistry. Ann Diagn Pathol 2001;5:148-54.
  • Levy J, Frenkel S, Baras M, Neufeld M, Pe'er J. Calcification in retinoblastoma: histopathologic findings and statistical analysis of...
  • Marback EF, Arias VE, Paranhos A, Jr., Soares FA, Murphree AL, Erwenne CM. Tumour angiogenesis as a prognostic factor for disease dissemination...
  • Abramson DH, Frank CM, Susman M, Whalen MP, Dunkel IJ, Boyd NW, 3rd. Presenting signs of retinoblastoma. J Pediatr 1998;132:505-8.
  • Kiss S, Leiderman YI, Mukai S. Diagnosis, classification, and treatment of retinoblastoma. Int Ophthalmol Clin 2008;48:135-47.
  • Jurkiewicz E, Pakula-Kosciesza I, Rutynowska O, Nowak K. Trilateral retinoblastoma: an institutional experience and review of the literature....
  • Finger PT, Harbour JW, Karcioglu ZA. Risk factors for metastasis in retinoblastoma. Surv Ophthalmol 2002;47:1-16.
  • Gunduz K, Muftuoglu O, Gunalp I, Unal E, Tacyildiz N. Metastatic retinoblastoma clinical features, treatment, and prognosis. Ophthalmology...
  • Vandhana S, Deepa PR, Jayanthi U, Biswas J, Krishnakumar S. Clinico-pathological correlations of fatty acid synthase expression in retinoblastoma:...
  • O'Brien JM. Retinoblastoma: clinical presentation and the role of neuroimaging. AJNR Am J Neuroradiol 2001;22:426-8.
  • Moll AC, Imhof SM, Meeteren AY, Boers M. At what age could screening for familial retinoblastoma be stopped? A register based study 1945-98....
  • Mahajan A, Crum A, Johnson MH, Materin MA. Ocular neoplastic disease. Semin Ultrasound CT MR 2011;32:28-37.
  • Balmer A, Munier F, Uffer S. [Diagnostic imaging of intraocular lesions in the child]. Klin Monbl Augenheilkd 1998;212:252-6.
  • Ghosh S, Mukhopadhyay S, Dutta SK, Chattopadhyay D, Biswas K. Diagnostic accuracy in retinoblastoma. J Indian Med Assoc 2010;108:509, 12-3.
  • Apushkin MA, Shapiro MJ, Mafee MF. Retinoblastoma and simulating lesions: role of imaging. Neuroimaging Clin N Am 2005;15:49-67.
  • Zilelioglu G, Gunduz K. Ultrasonic findings in intraocular retinoblastoma and correlation with histopathologic diagnosis. Int Ophthalmol 1995;19:71-5.
  • de Graaf P, Barkhof F, Moll AC, et al. Retinoblastoma: MR imaging parameters in detection of tumor extent. Radiology 2005;235:197-207.
  • Shields CL, Mashayekhi A, Luo CK, Materin MA, Shields JA. Optical coherence tomography in children: analysis of 44 eyes with intraocular tumors...
  • Shields JA, Shields CL, Parsons HM. Differential diagnosis of retinoblastoma. Retina 1991;11:232-43.
  • Shields JA, Parsons HM, Shields CL, Shah P. Lesions simulating retinoblastoma. J Pediatr Ophthalmol Strabismus 1991;28:338-40.
  • Maki JL, Marr BP, Abramson DH. Diagnosis of retinoblastoma: how good are referring physicians? Ophthalmic Genet 2009;30:199-205.
  • Lin P, O'Brien JM. Frontiers in the management of retinoblastoma. Am J Ophthalmol 2009;148:192-8.
  • Shields CL, Mashayekhi A, Au AK, et al. The International Classification of Retinoblastoma predicts chemoreduction success. Ophthalmology...
  • Shields CL, Shields JA. Basic understanding of current classification and management of retinoblastoma. Curr Opin Ophthalmol 2006;17:228-34.
  • Linn Murphree A. Intraocular retinoblastoma: the case for a new group classification. Ophthalmol Clin North Am 2005;18:41-53, viii.
  • Shields CL, Shields JA. Retinoblastoma management: advances in enucleation, intravenous chemoreduction, and intra-arterial chemotherapy. Current...
  • Mallipatna AC, Sutherland JE, Gallie BL, Chan H, Heon E. Management and outcome of unilateral retinoblastoma. J AAPOS 2009;13:546-50.
  • Shields CL, Honavar SG, Meadows AT, Shields JA, Demirci H, Naduvilath TJ. Chemoreduction for unilateral retinoblastoma. Arch Ophthalmol 2002;120:1653-8.
  • Chantada GL, Qaddoumi I, Canturk S, et al. Strategies to manage retinoblastoma in developing countries. Pediatr Blood Cancer 2011;56:341-8.
  • Hernandez JC, Brady LW, Shields JA, et al. External beam radiation for retinoblastoma: results, patterns of failure, and a proposal for treatment...
  • Toma NM, Hungerford JL, Plowman PN, Kingston JE, Doughty D. External beam radiotherapy for retinoblastoma: II. Lens sparing technique. Br...
  • Abramson DH, Frank CM. Second nonocular tumors in survivors of bilateral retinoblastoma: a possible age effect on radiation-related risk....
  • Reisner ML, Viegas CM, Grazziotin RZ, et al. Retinoblastoma--comparative analysis of external radiotherapy techniques, including an IMRT technique....
  • Shields CL, Shields JA, De Potter P, et al. Plaque radiotherapy in the management of retinoblastoma. Use as a primary and secondary treatment....
  • Shields CL, Meadows AT, Leahey AM, Shields JA. Continuing challenges in the management of retinoblastoma with chemotherapy. Retina 2004;24:849-62.
  • Shields CL, Mashayekhi A, Cater J, Shelil A, Meadows AT, Shields JA. Chemoreduction for retinoblastoma. Analysis of tumor control and risks...
  • Schefler AC, Cicciarelli N, Feuer W, Toledano S, Murray TG. Macular retinoblastoma: evaluation of tumor control, local complications, and...
  • Gombos DS, Kelly A, Coen PG, Kingston JE, Hungerford JL. Retinoblastoma treated with primary chemotherapy alone: the significance of tumour...
  • Shin JY, Kim JH, Yu YS, et al. Eye-preserving therapy in retinoblastoma: prolonged primary chemotherapy alone or combined with local therapy....
  • Gombos DS, Hungerford J, Abramson DH, et al. Secondary acute myelogenous leukemia in patients with retinoblastoma: is chemotherapy a factor?...
  • Houston SK, Murray TG, Wolfe SQ, Fernandes CE. Current update on retinoblastoma. International Ophthalmology Clinics 2011;51:77-91.
  • Abramson DH, Frank CM, Dunkel IJ. A phase I/II study of subconjunctival carboplatin for intraocular retinoblastoma. Ophthalmology 1999; 106:1947-50.
  • Brodie SE, Pierre Gobin Y, Dunkel IJ, Kim JW, Abramson DH. Persistence of retinal function after selective ophthalmic artery chemotherapy...
  • Abramson DH, Dunkel IJ, Brodie SE, Kim JW, Gobin YP. A phase I/II study of direct intraarterial (ophthalmic artery) chemotherapy with melphalan...
  • Abramson DH, Dunkel IJ, Brodie SE, Marr B, Gobin YP. Superselective ophthalmic artery chemotherapy as primary treatment for retinoblastoma...
  • Shields CL, Shields JA, Kiratli H, De Potter PV. Treatment of retinoblastoma with indirect ophthalmoscope laser photocoagulation. J Pediatr...
  • Shields CL, Santos MC, Diniz W, et al. Thermotherapy for retinoblastoma. Arch Ophthalmol 1999; 117:885-93.
  • Shields JA, Parsons H, Shields CL, Giblin ME. The role of cryotherapy in the management of retinoblastoma. Am J Ophthalmol 1989;108:260-4.
  • Honavar SG, Singh AD, Shields CL, et al. Postenucleation adjuvant therapy in high-risk retinoblastoma. Arch Ophthalmol 2002; 120:923-31.
  • Boutrid H, Pina Y, Cebulla CM, et al. Increased hypoxia following vessel targeting in a murine model of retinoblastoma. Invest Ophthalmol...
  • Fortunato P, Pillozzi S, Tamburini A, et al. Irresponsiveness of two retinoblastoma cases to conservative therapy correlates with up- regulation...
  • Boutrid H, Jockovich ME, Murray TG, et al. Targeting hypoxia, a novel treatment for advanced retinoblastoma. Invest Ophthalmol Vis Sci 2008;49:2799-805.
  • Pina Y, Boutrid H, Murray TG, et al. Impact of tumor-associated macrophages in LH(BETA)T(AG) mice on retinal tumor progression: relation to...
  • Chakraborty S, Khare S, Dorairaj SK, Prabhakaran VC, Prakash DR, Kumar A. Identification of genes associated with tumorigenesis of retinoblastoma...