Resumen de Neurocognitive endophenotypes: an update on the Field.

Jorge Mauricio Cuartas Arias, Douglas Londoño

• The endophenotypeconstruct,initially formulated by Lewis and Gottesman in the 1960s, referredto an indicator of vulnerability,not necessarily expressed as a clinical marker of status.However,this subclinical marker was established in the phenotype as a component that co-segregatedwith the genetic disease background. The endophenotype notonly determinedboth potential and differentiated types within the same phenotype of interest, but also related to changes in the prognosis and evolution of the syndrome or disorder.