Activity of energy, glutamate, and glutathione metabolism enzymes in blood cells of elderly patients with depression

• Olga Savushkina ^[1] ; Irina Boksha ^[2] ; Tatyana Prokhorova ^[1] ; Elena Tereshkina ^[1] ; Tatyana Safarova ^[1] ; Olga Yakovleva ^[1] ; Vladimir Kornilov ^[1] ; Elena Shipilova ^[1] ; Elena Vorobyeva ^[1] ; Gulnur Burbaeva ^[1]
  1. [1] Federal State Budgetary Scientific Institution “Mental Health Research Centre”, Moscow, Russia
  2. [2] Federal State Budgetary Scientific Institution “Mental Health Research Centre”, Moscow, Russia/ N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia
• Localización: European journal of psychiatry, ISSN 0213-6163, Vol. 36, Nº 4, 2022, págs. 288-293
• Idioma: inglés
• DOI: 10.1016/j.ejpsy.2022.05.001
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• Resumen

  • Heterogeneity of depression in older adults is a challenge for the development of person-centered treatment. To address this, we studied glutamate and glutathione metabolism enzymes in blood cells in 53 older adult patients with depression and 20 controls. Patients with depression had decreased platelet glutathione-S-transferase and erythrocyte glutathione reductase. The biochemical and clinical data contributed to three clinical clusters that are not linked to the onset of depression or its duration but were related to anxiety, cerebrovascular and cardiovascular comorbidities, including parkinsonian features such as tremor, akathisia, and rigidity. These findings could aid person-centered diagnosis and outcomes and timely successful treatment(s) of depression in older adults.