Acceso usuarios
Fernanda de Toledo Gonçalves, Kevin Pacheco Barrios, Ingrid Rebello Sanchez, Luis Castelo Branco, Paulo S. de Melo, Joao Parente, Alejandra Cardenas Rojas, Isabela Firigato, Anne Victorio Pessotto, Marta Imamura, Marcel Simis, Linamara Battistella, Felipe Fregni
Background/objective Chronic pain due to osteoarthritis (OA) is a prevalent cause of global disability. New biomarkers are needed to improve treatment allocation, and genetic polymorphisms are promising candidates.
Method We aimed to assess the association of OPRM1 (A118G and C17T) and brain-derived neurotrophic factor (BDNF [G196A]) polymorphisms with pain-related outcomes and motor cortex excitability metrics (measured by transcranial magnetic stimulation) in 113 knee OA patients with chronic pain. We performed adjusted multivariate regression analyses to compare carriers versus non-carriers in terms of clinical and neurophysiological characteristics at baseline, and treatment response (pain reduction and increased cortical inhibitory tonus) after rehabilitation.
Results Compared to non-carriers, participants with polymorphisms on both OPRM1 (A118G) and BDNF (G196A) genes were less likely to improve pain after rehabilitation (85 and 72% fewer odds of improvement, respectively). Likewise, both carriers of OPRM1 polymorphisms (A118G and C17T) were also less likely to improve cortical inhibition (short intracortical inhibition [SICI], and intracortical facilitation [ICF], respectively). While pain and cortical inhibition improvement did not correlate in the total sample, the presence of OPRM1 (A118G) and BDNF (G196A) polymorphisms moderated this relationship.
Conclusions These results underscore the promising role of combining genetic and neurophysiological markers to endotype the treatment response in this population.
