An insight into anti-thyroid peroxidase (TPO) positive cognitive impairment: Analysis of four unusual cases and plea for pragmatism

• S. Dubey ^[2] ; S. Chatterjee ^[3] ; R. Ghosh ^[4] ; M.J. Dubey ^[5] ; S. Chatterjee ^[6] ; D. Lahiri ^[2] ; P.J. Modrego ^[1]
  1. [1] Hospital Miguel Servet

     Hospital Miguel Servet

     Zaragoza, España

     
  2. [2] Department of Neuromedicine, Bangur Institute of Neurosciences, Institute of Post Graduate Medical Education and Research & SSKM Hospital, Kolkata, West Bengal, India
  3. [3] Department of General Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India
  4. [4] Department of General Medicine, Burdwan Medical College and Hospital, Burdwan, West Bengal, India
  5. [5] Department of Psychiatry, Behrampore Mental Hospital, Behrampore, Mushridabad, West Bengal, India
  6. [6] Institute of Psychiatry, Institute of Post Graduate Medical Education and Research & SSKM Hospital, Kolkata, West Bengal, India

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• Localización: European journal of psychiatry, ISSN 0213-6163, Vol. 35, Nº 1, 2021, págs. 56-61
• Idioma: inglés
• DOI: 10.1016/j.ejpsy.2020.09.002
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• Resumen

  • Cognitive impairment and varied psychiatric manifestations are common in thyroid disorders. But autoimmune thyroid disorders masquerading as dementia or psychotic disorders without other overt systemic features of dysthyroidism are rare. Here we are presenting a detailed analysis of four heterogeneous cases of thyroid related cognitive impairments mimicking and fulfilling criteria of known psychiatric diagnosis for a brief period of time, requiring multiple psychotropic medications without any significant improvement. Cognitive impairment and behavioral abnormalities with a known psychiatric diagnosis, with unknown temporal profiling of anti-thyroid peroxidase (TPO) positivity, without encephalopathy and subsequent complete or partial responsiveness with levothyroxin, point towards a possible new entity not well explored so far.