Does experienced pain affects local brain volumes? Insights from a clinical acute pain model

• Laura Torrecillas-Martínez ^[1] ; Andrés Catena ^[2] ; Francisco O'Valle ^[2] ; Miguel Padial-Molina ^[2] ; Pablo Galindo-Moreno ^[2]
  1. [1] University of Pennsylvania

     University of Pennsylvania

     City of Philadelphia, Estados Unidos

     
  2. [2] Universidad de Granada

     Universidad de Granada

     Granada, España

     
• Localización: International journal of clinical and health psychology, ISSN 1697-2600, Vol. 19, Nº. 2, 2019, págs. 115-123
• Idioma: inglés
• DOI: 10.1016/j.ijchp.2019.01.001
• Títulos paralelos:
  • ¿Afecta el dolor al volumen local del cerebro? Aportaciones desde un modelo clínico de dolor agudo
• Enlaces
  • Texto completo (pdf)
• Resumen
  • español

    Antecedentes/Objetivo:Se trata de determinar la asociación entre dolor percibido y morfometría cerebral en tres etapas postquirúrgicas (anestesia, dolor y analgesia), en un modelo de dolor agudo. Método:Se obtuvo una imagen cerebral estructural de alta resolución y posteriormente se extrajeron los terceros molares mandibulares impactados. Se realizó un análisis morfométrico para determinar volumen cerebral y forma de núcleos subcorticales. Se realizaron análisis de regresión múltiple, siendo la intensidad del dolor el predictor, y el volumen y la forma de los núcleos subcorticales, medidos pre-cirugía, las variables dependientes. Resultados:El dolor experimentado fue mayor en la etapa de dolor que en las de anestesia y analgesia, y mayor en anestesia que en analgesia. El dolor se asoció con el volumen de materia gris en áreas corticales (insula, giros frontal medial y temporal, precuneus y cingulado anterior) y subcorticales (hipocampo, tálamo, putamen y amígdala). El número de áreas asociadas al dolor experimentado fue mayor en la etapa de dolor que en las de anestesia y analgesia. Conclusiones:La relación entre volumen cerebral regional y forma de núcleos subcorticales con la intensidad del dolor no es fijo, sino que varía en función de la etapa post-quirúrgica (magnitud del dolor).

  • English

    Background/Objective:To study pain-brain morphometry associations as a function of post-surgery stages (anesthesia, pain and analgesia) in an acute pain model. Method:Impacted mandible third molar were extracted. Before surgery, an anatomical T1 scan was obtained. Regional brain volumen and subcortical nuclei shapes were obtained. Statistical analyses were done using multiple regression, being pain scores the predictors and voxel volumes, subcortical nuclei volumes and subcortical nuclei shapes, the outcomes. Results:Pain was significantly larger at pain than at anesthesia and analgesia stages, and was higher during anesthesia than during analgesia. Pain intensity was related to grey matter in several cortical (Insula, Mid Frontal and Temporal Gyruses, Precuneus, Anterior Cingulate), and subcortical nuclei (Hippocampus, Thalamus, Putamen, Amygdala), depending of the post-surgical stage. A larger number of brain areas showed significance at pain that at anesthesia and analgesia stages. Conclusions:The relationships of regional brain volumes and subcortical nuclei shapes with pain scores seemed to be unsteady, as they changed with the patient's actual pain stage.

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