The study of the antisaccade performance and contingent negative variation characteristics in first-episode and chronic schizophrenia patients

• Anna V. Kirenskaya ^[1] ; Andrej A. Tkachenco ^[1] ; Vladimir Yu. Novototsky-Vlasov ^[1]
  1. [1] Federal Medical Research Centre for Psychiatry and Narcology

     Federal Medical Research Centre for Psychiatry and Narcology

     Rusia

     
• Localización: The Spanish Journal of Psychology, ISSN 1138-7416, Vol. 20, 2017
• Idioma: inglés
• DOI: 10.1017/sjp.2017.40
• Enlaces
  • Texto completo
• Resumen

  • The study tested whether the antisaccade (AS) performance and Contingent Negative Variation (CNV) measures differed between the first-episode and chronic patients to provide the evidence of PFC progressive functional deterioration. Subjects included 15 first-episode and 20 chronic schizophrenic patients (with the duration of illness more than 5 years), and 21 control subjects. The first-episode and chronic patients had significantly elevated error percent (p < .05, effect size 1.10 and p < .001, effect size 1.25), increased AS latencies (p < .01, effect size 1.18 and p < .001, effect size 1.69), and increased latencies variability (p < .01, effect size 1.52 and p < .001, effect size 1.37) compared to controls. Chronic patients had marginally significant increase of the response latency (p = .086, effect size .78) and latency variability (p < .099, effect size .63) compared to first-episode ones. Results of CNV analysis revealed that chronic patients only exhibited robustly declined frontal CNV amplitude at Fz (p < .05, effect size .70), F3 (p < .05, effect size .88), and F4 (p < .05, effect size .71) sites compared to controls. The obtained results might be related to specific changes in prefrontal cortex function over the course of schizophrenia.

• Referencias bibliográficas
  • Annett M. (1970). A classification of hand preference by association analysis. British Journal of Psychology, 61, 303–321. https://doi.org/10.1111/j.2044-8295.1970.tb01248.x
  • Bachmann S., Bottmer C., Pantel J., Amann M., Essig M., Schad L. R., & Schröder J. (2004). MRI-morphometric changes in first-episode schizophrenia...
  • Broerse A., Crawford T. J., & den Boer J. A. (2001). Parsing cognition in schizophrenia using saccadic eye movements: A selective overview....
  • Brown M. R., Vilis T., & Everling S. (2007). Frontoparietal activation with preparation for antisaccades. Journal of Neurophysiology,...
  • Brunia C. H. M. (1999). Neural aspects of anticipatory behavior. Acta Psychologica, 101, 213–242. https://doi. org/10.1016/S0001-6918(99)00006-2
  • Callicott J. H., Mattay V. S., Verchinski B. A., Marenco S., Egan M. F., & Weinberger D. R. (2003). Complexity of prefrontal cortical...
  • Camchong J., Dyckman K. A., Austin B. P., Clementz B. A., & McDowell J. E., (2008). Common neural circuitry supporting volitional saccades...
  • Cordones I., Gómez C. M., & Escudero M. (2013). Cortical dynamics during the preparation of antisaccadic and prosaccadic eye movements...
  • Crawford T. J., Haeger B., Kennard C., Reveley M. A., & Henderson L. (1995). Saccadic abnormalities in psychotic patients. I. Neuroleptic-free...
  • Curtis C. E., & D’Esposito M. (2003). Success and failure suppressing reflexive behavior. Journal of Cognitive Neuroscience, 15, 409–418....
  • Damilou A., Apostolakis S., Thrapsanioti E., Theleritis C., & Smyrnis N. (2016). Shared and distinct oculomotor function deficits in schizophrenia...
  • DeLisi L. E. (2008). The concept of progressive brain change in schizophrenia: Implications for understanding schizophrenia. Schizophrenia...
  • DeLisi L. E., Sakuma M., Tew W., Kushner M., Hoff A. L., & Grimson R. (1997). Schizophrenia as a chronic active brain process: A study...
  • Doricchi F., Perani D., Incoccia C., Grassi F., Cappa S. F., Bettinardi V., … Fazio F. (1997). Neural control of fast-regular saccades and...
  • Eisenberg D. P., & Berman K. F. (2010). Executive function, neural circuitry, and genetic mechanisms in schizophrenia. Neuropsychopharmacology,...
  • Ettinger U., Kumari V., Chitnis X. A., Corr P. J., Crawford T. J., Fannon D. G., … Sharma T. (2004). Volumetric neural correlates of antisaccade...
  • Evdokimidis I., Smyrnis N., Constantinidis T. S., Gourtzelidis P., & Papageorgiou C. (2001). Frontalparietal activation differences observed...
  • Everling S., Krappmann P., & Flohr H. (1997). Cortical potentials preceding proand antisaccades in man. Electroencephalography and Clinical...
  • Ford K. A., Goltz H. C., Brown M. R. G., & Everling S. (2005). Neural processes associated with antisaccade task performance investigated...
  • Fukushima J., Morita N., Fukushima K., Chiba T., Tanaka S., & Yamashita I. (1990). Voluntary control of saccadic eye movements in patients...
  • Funahashi S., Chafee M. V., & Goldman-Rakic P. S. (1993). Prefrontal neuronal activity in Rhesus monkeys performing a delayed antisaccade...
  • Gale H. J., & Holzman P. S. (2000). A new look at reaction time in schizophrenia. Schizophrenia Research, 46, 149–165. https://doi.org/10.1016/S0920-9964(00)00006-2
  • Gómez C. M., & Flores A. (2011). A neurophysiological evaluation of a cognitive cycle in humans. Neuroscience & Biobehavioral Review,...
  • Gomez C. M., Marco J., & Grau C. (2003). Visuo-motor cortical network of the contingent negative variation. NeuroImage, 20, 216–226. https://doi.org/10.1016/...
  • Gur R. E., Cowell P., Turetsky B. I., Gallacher F., Cannon T., Bilker W., & Gur R. C. (1998). A follow-up magnetic resonance imaging study...
  • Ho B. C., Andreasen N. C., Nopoulos P., Arndt S., Magnotta V., & Flaum M. (2003). Progressive structural brain abnormalities and their...
  • Hulshoff Pol H. E., & Kahn R. S. (2008). What happens after the first episode? A review of progressive brain changes in chronically ill...
  • Hutton S. B., Crawford T. J., Puri B. K., Duncan L. J., Chapman M., Kennard C., … Joyce E. M. (1998). Smooth pursuit and saccadic abnormalities...
  • Hutton S. B., & Ettinger U. (2006). The antisaccade task as a research tool in psychopathology: A critical review. Psychophysiology, 43,...
  • Jansma J. M., Ramsey N. F., van der Wee N. J. A., & Kahn R. S. (2004). Working memory capacity in schizophrenia: A parametric fMRI study....
  • Johnston K., & Everling S. (2008). Neurophysiology and neuroanatomy of reflexive and voluntary saccades in nonhuman primates. Brain and...
  • Kang S. S., Dionisio D. P., & Sponheim S. R. (2011). Abnormal mechanisms of antisaccade generation in schizophrenia patients and unaffected...
  • Karoumi B., Ventre-Dominey J., Vighetto A., Dalery J., & d’Amato T. (1998). Saccadic eye movements in schizophrenic patients. Psychiatry...
  • Kirenskaya A. V., Kamenskov M. Y., Myamlin V. V., Novototsky-Vlasov V. Y., & Tkachenko A. A. (2013). The antisaccade task performance...
  • Kirenskaya A. V., Myamlin V. V., Novototsky-Vlasov V. Y., Pletnikov M. V., & Kozlovskaya I. B. (2011). The contingent negative variation...
  • Klein C., Heinks T., Andresen B., Berg P., & Moritz S. (2000). Impaired modulation of the saccadic contingent negative variation preceeding...
  • Levy D. L., Mendell N. R., & Holzman P. S. (2004). The antisaccade task and neuropsychological tests of prefrontal cortical integrity...
  • Manoach D. S. (2003). Prefrontal cortex dysfunction during working memory performance in schizophrenia: Reconciling discrepant findings. Schizophrenia...
  • Mathalon D. H., Sullivan E. V., Lim K. O., & Pfefferbaum A. (2001). Progressive brain volume changes and the clinical course of schizophrenia...
  • McDowell J. E., Brown G. G., Paulus M., Martinez A., Stewart S. E., Dubowitz D. J., & Braff D. L. (2002). Neural correlates of refixation...
  • McDowell J. E., Dyckman K. A., Austin B. P., & Clementz B. A. (2008). Neurophysiology and neuroanatomy of reflexive and volitional saccades:...
  • McDowell J. E., Myles-Worsley M., Coon H., Byerley W., & Clementz B. A. (1999). Measuring liability for schizophrenia using optimized...
  • Novototsky-Vlasov V. Y., Garakh J. V., & Kovalev V. P. (2007). A method for repetitive artifact suppression in multichannel EEG recordings....
  • O’Driscoll G. A., Alpert N. M., Matthysse S. W., Levy D. L., Rauch S. L., & Holzman P. S. (1995). Functional neuroanatomy of antisaccade...
  • Olabi B., Ellison-Wright I., McIntosh A. M., Wood S. J., Bullmore E., & Lawrie S. M. (2011). Are there progressive brain changes in schizophrenia?...
  • Richards J. E. (2003). Cortical sources of event-related potentials in the prosaccade and antisaccade task. Psychophysiology, 40, 878–894....
  • Ruchkin D. S., Sutton S., Mahaffey D., & Glaser J. (1986). Terminal CNV in the absence of motor response. Electroencephalography and Clinical...
  • Salisbury D. F., Kuroki N., Kasai K., Shenton M. E., & McCarley R. W. (2007). Progressive and interrelated functional and structural evidence...
  • Schall J. D. (2002). The neural selection and control of saccades by the frontal eye field. Philosophical Transactions of the Royal Society...
  • Sereno A. B., & Holzman P. S. (1995). Antisaccades and smooth pursuit eye movements in schizophrenia. Biological Psychiatry, 37, 394–401....
  • Slavutskaya M. V., Kirenskaya A. V., Novototskii-Vlasov V. Yu., Shul’govskii V. V., & Kozlovskaya I. B. (2005). Slow cortical potentials...
  • Smyrnis N., Karantinos T., Malogiannis I., Theleritis C., Mantas A., Stefanis N. C., … Evdokimidis I. (2009). Larger variability of saccadic...
  • Stirling J., Hellewell J., Blakey A., & Deakin W. (2006). Thought disorder in schizophrenia is associated with both executive dysfunction...
  • Thermenos H. W., Goldstein J. M., Buka S. L., Poldrack R. A., Koch J. K., Tsuang M. T., & Seidman L. J. (2005). The effect of working...
  • Turetsky B. I., Calkins M. E., Light G. A., Olincy A., Radant A. D., & Swerdlow N. R. (2006). Neurophysiological endophenotypes of schizophrenia:...
  • Weinberger D. R., Egan M. F., Bertolino A., Callicott J. H., Mattay V. S., Lipska B. K., … Goldberg T. E. (2001). Prefrontal neurons and the...
  • Zaykin D. V., Zhivotovsky L. A., Westfall P. H., & Weir B. S. (2002). Truncated product method for combining p-values. Genetic Epidemiology,...