Fibromialgia: Un trastorno de estrés oxidativo

• Autores: Francisco Javier Hidalgo Tallón
• Localización: Revista de la Sociedad Española del Dolor (SED), ISSN 1134-8046, Vol. 19, Nº. 2, 2012, págs. 95-100
• Idioma: español
• Títulos paralelos:
  • Fibromyalgia: A disorder of oxidative stress
• Enlaces
  • Texto completo (pdf)
• Dialnet Métricas: 4 Citas
• Resumen
  • español

    La fibromialgia es una enfermedad de prevalencia elevada cuya etiopatogenia aún no es bien conocida. Se han descrito implicaciones de corte psico-neuro-endocrino-inmunológico, lo que justifica una clínica dispar en la que predominan el dolor, la fatiga crónica, los trastornos del sueño y los trastornos afectivos. En este trabajo se revisan las características principales de la enfermedad desde el punto de vista del estrés oxidativo como base biológica del deterioro orgánico y de los principales síntomas que padece el paciente.

  • English

    Fibromyalgia is a disease of high prevalence whose pathogenesis still is not well known. Implications of psycho-neuro-endocrine-immune systems have been described which justifies the clinic, dominated by pain, chronic fatigue, sleep disorders and affective disorders. In this work the main features of the disease are reviewed from the point of view of oxidative stress as the biological basis of the organic deterioration and the main symptoms that the patient suffers.

• Referencias bibliográficas
  • Grant, JT. (2003). The epidemiology of chronic generalized musculoskeletal pain. Best Pract Res Clin Rheumatol. 17. 547
  • Wolfe, F, Ross, K, Anderson, J, Russell, J, Hebert, L. (1995). The prevalence and characteristics of fibromyalgia in the general population....
  • (2009). Editorial. Rev Soc Esp Dolor. 16. 417
  • Van Houdenhove, B, Egle, UT. (2004). Fibromyalgia: A stress disorder?. Psychotherapy and psychosomatics. 73. 267
  • Van Houdenhove, B, Luyten, P, Egle, UT. (2009). Stress as a key concept in chronic widespread pain and fatigue disorders. Journal of musculosk...
  • Arnold, LA, Leon, T, Whalen, E, Barret, J. Relationships among pain and depressive and anxiety symptoms in clinical trials of pregabaline...
  • Walker, EA, Keegan, D, Gardner, G, Sullivan, M, Katon, WJ, Bernstein, D. (1997). Psychological factors in fibromyalgia compared with rheumatoid...
  • Sarandol, A, Sarandol, E, Eker, SS, Erdinc, S, Vatansever, E, Kirli, S. (2007). Major depressive disorder is acompained with oxidative stress:...
  • Felicity, NG, Berk, M, Dean, O, Bush, AI. (2008). Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int...
  • Pongratz, D, Spath, M. (2001). Fibromyalgie. Fortschr Neurol Psychiatr. 69. 189
  • Majid, A. (2003). The cause of fibromyalgia: the respiratory-to-fermentative shift (the dysox state) in ATP production. J Integrative Medicine....
  • Reid, MB. (2008). Free radicals and muscle fatigue: Of ROS, canaries, and the IOC. Free radical biology and and medicine. 44. 169
  • Pall, ML. (2001). Common etiology of posttraumatic stress disorder, fibromialgia, chronic fatigue síndrome and multiple sensitivity via elevated...
  • Kennedy, G, Khan, F, Hill, A, Underwood, C, Belch, JJ. (2010). Biochemical and vascular aspects of pediatric chronic fatigue syndrome. Arch...
  • Bagge, E, Bengtsson, BA, Carlsson, L, Carlsson, J. (1998). Low growth hormone secretion in patients with fibromyalgia: A preliminary report...
  • Wolfe, F, Russell, IJ, Vipraio, G, Ross, K, Anderson, J. (1997). Serotonin levels, pain treshold, and fibromyalgia symtoms in the general...
  • Russell, IJ, Michalek, JE, Vipraio, GA, Fletcher, EM, Wall, K. (1989). FERUM amino acids in fibrositis/fibromyalgia síndrome. J Rheumatol....
  • Bagis, S, Tamer, L, Sahin, G, Bilgin, R, Guler, H, Ercan. (2005). Free radicals and antioxidants in primary fibromyalgia: An oxidative stress...
  • Gao, X, Kim, HK, Chung, JM, Chung, K. (2007). Reactive oxygen species (ROS) are involved in enhancement of NMDA-receptor phosphorilation in...
  • Schwartz, ES, Kim, HY, Wang, J, Lee, I, Klann, E, Chung, JM. (2009). Persistent pain is dependen ton spinal mitocondrial antioxidant levels....
  • Eisinger, J, Gandolfo, C, Zakarian, H, Ayavou, T. (1997). Reactive oxygen species, antioxidant status and fibromyalgia. Journal of Musculoskeletal...
  • Hein, G, Franke, S. (2002). Are advanced glycation end-product-modified proteins of pathogenic importance in fibromialgia?. Rheumatology....
  • Bagis, S, Tamer, L, Sahin, G, Bilgin, R, Guler, H, Ercan, B. (2003). Free radicals and antioxidants in primary fibromyalgia: an oxidative...
  • Ozgocmen, S, Ozyurt, H, Sogut, S, Akyol, O, Ardicoglu, O, Yildizhan, H. (2006). Antioxidant status, lipid peroxidation and nitric oxide in...
  • Lund, N, Bengtsson, A, Thorborg, P. (1986). Muscle tissue oxygen pressure primary fibromyalgia. Scand J Rheumatol. 15. 165
  • Henriksson, KG. (1988). Muscle pain in neuromuscular disorders and primary fibromyalgia. European Journal of Applied Physiology and Occupational...
  • Bengtsson, A, Henriksson, KG. (1989). The muscle in fibromyalgia: A review of Swedish studies. J Rheumatol. 16. 144
  • Morf, S, Amann-Vesti, B, Forster, A, Franzeck, U, Koppensteiner, R, Uebelhart, D, Sprott, H. (2005). Microcirculation abnormalities in patients...
  • Mclver, KL, Evans, C, Kraus, RM, Ispas, L, Sciotti, VM, Hickner, RC. (2006). NO-mediated alterations in skeletal muscle nutritive blood flow...
  • Ajamieh, H, Merino, N, Candelario-Jali, E, Menéndez, S, Martínez, G, Re, L. (2002). Similar protective effect of ischemic and ozone oxidative...
  • Ajamieh, HH, Menéndez, S, Martínez-Sánchez, G, Candelario-Jalil, E, Re, L, Giuliani, A. (2004). Effects of ozone oxidative preconditioning...
  • Ajamieh, H, Berlanga, J, Merino, N, Sánchez, GM, Carmona, AM, Cepero, SM. (2005). Role of protein synthesis in the protection conferred by...
  • Badía, X, Muriel, C, Gracia, A, Núñez-Olarte, JM. (2003). Validation of the spanish version of the Brief Pain Inventory in patients with oncological...
  • Bocci, V. (1992). Ozonization of blood for the therapy of viral diseases and inmunodeficiencies: A hipothesis. Medical Hipothesis. 39. 30
  • Bocci, V. (1997). Ozone as a biorregulator: Pharmacology and toxicology of ozonotheraphy. J Biol Reg. 31. 213
  • Borrego, A, Zamora, ZB, González, R, Romay, C, Menéndez, S, Hernández, F. (2004). Protection by ozone preconditioning is mediated by the antioxidant...
  • Buckley, RD, Hackney, JD, Clark, K, Posin, C. (1975). Ozone and human blood. Arch Environ Health. 30. 40
  • Calunga, JL, Zamora, ZB, Borrego, A, Del Río, S, Barber, E, Menéndez, S. (2005). Ozone Therapy on Rats Submitted to Subtotal Nephrectomy:...
  • Calunga, JL, Menéndez, S, Barber, E, Merino, N, Cruz, E. (2003). Ozone biological response in kidneys of rats submitted to warm ischemia....
  • Clavo, B, Pérez, JL, López, L, Suárez, G, Lloret, M, Rodríguez, V. (2003). Effect of Ozone Therapy on Muscle Oxygenation. The journal of alternative...
  • Clavo, B, Pérez, JL, López, L, Suárez, G, Lloret, M, Rodríguez, V. (2004). Ozone Therapy on Cerebral Blood Flow: A Preliminary Report. Evidence-based...
  • Clavo, B, Ruiz, A, Lloret, M, López, L, Suárez, G, Macías, D, Rodríguez, V. (2004). Adjuvant Ozonetherapy in Advanced Head and Neck Tumors:...
  • Guy, W. (1976). ECDEU Assessment Manual for Psychopharmacology. U.S. Department of Health, Education, and Welfare. Rockville^eMD MD.
  • Hernández-Rosales, FA, Calunga-Fernández, JL, Turrent-Figueras, J, Menéndez-Cepero, S, Montenegro-Perdomo, A. (2005). Ozone therapy effects...
  • Hussam, H, Ajamieh, H, Berlanga, J, Merino, N, Sánchez, G M, Carmona, A M, Cepero, S M, Giuliani, A, Re, L, León, O S. (2005). Role of protein...
  • Jacobs, M-T. (1982). Untersuchung Über Zwischenfalle Und Typische Komplikationen In Der Ozon-Sauerstoff-Therapie. Ozo Nachrichten. 1. 5
  • Martínez-Sánchez, G, Al-Dalain, SM, Menéndez, S, Re, L, Giuliani, A, Candelario-Jalil, E. (2005). Therapeutic efficacy of ozone in patients...
  • Pioro-Boisset, M, Esdaile, JM, Fitzcharles, MA. (1996). Artritis Care Res. 9. 13
  • Rivera, J, González, T. (2004). The Fibromyalgia Impact Questionnaire: a validated Spanish version to assess the health status in women with...
  • Royuela, A, Macías, JA. (1997). Propiedades clinimétricas de la versión castellana del cuestionario de Pittsburgh. Vigilia-Sueño. 9. 81-94
  • Sanz, J, Perdigón, AL, Vázquez, C. (2003). Adaptación española del inventario para la depresión de Beck-II: 2. Propiedades psicométricas en...
  • Valacchi, G, Bocci, V. (2000). Studies on the biological effects of ozone: 11. Release of factors from human endothelial cells. Mediators...
  • Viebahn-Hänsler, R. (1999). Ozon-Handbuch: Grundlagen. Prävention. Therapie. Ecomed. Landsberg.
  • Vilagut, G, Ferrer, M, Rajmil, L, Rebollo, P. (2005). El cuestionario de salud SF-36 español: una década de experiencia y nuevos desarrollos....
  • Verrazzo, G, Coppola, L, Luongo, C. (1995). Hyperbaric oxygen, oxygen-ozone therapy, and reologic parameters on blood in patients with peripheral...
  • Wolfe, F, Smythe, HA, Yunus, MB, Bennett, RM, Bombardier, C, Goldenberg, DL. (1990). The American College of Rheumatology 1990 criteria for...