Acceso usuarios
Margarita V. Alfimova, Vera Golimbet, Tatyana Lezheiko, Galina Korovaitseva
Intense effort is directed toward searching for associations between genes and neuropsychological measures of executive functions. In contrast, the impact of genetic polymorphisms on self-rating of everyday executive functioning has not been investigated so far. This study was designed to test associations of self-reported executive functioning, measured with the Behavior Rating Inventory of Executive Function (BRIEF-A), with dopaminergic and serotoninergic genes in non-clinical population and to assess impact of neuropsychological and personality characteristics on these associations. One hundred healthy adults completed the BRIEF-A, personality inventories SPQ-74, STAI, MMPI, and neuropsychological tests for executive functions. Polymorphisms in the DRD4, COMT, DRD2, HTR2A, and SLC6A4 genes were genotyped. We revealed a significant main effect of the SLC6A4’s 5-HTTLPR polymorphism on BRIEF-A scores (F = 2.21, P = .018, η2 = .24). Among the BRIEF-A measures, the genotype effect was significant for the Plan/Organize (F = 7.34, P = .008, η2 = .07) and Task Monitor scales (F = 4.33, P = .04, η2 = .04), and the Metacognition index (F = 4.21, P = .043, η2 = .04). Carriers of the short allele reported fewer problems than homozygotes for the long allele. Correlations of the BRIEF-A measures with neuropsychological variables were weak, while those with personality characteristics were strong, with trait anxiety being the most powerful predictor of the BRIEF-A scores. However, the relationship between the 5-HTTLPR and BRIEF-A scores remained significant when trait anxiety was controlled for. The results suggest a potential role of the 5-HTTLPR in self-reported everyday task planning and monitoring.
