A Comparison of the Effectiveness of Three Drug Regimens on Cognitive Performance of Patients with Parkinson's disease

• Golita Emsaki ^[1] ; Karim Asgari ^[1] ; Hossein Molavi ^[1] ; Ahmad Chitsaz ^[2]
  1. [1] University of Isfahan

     University of Isfahan

     Irán

     
  2. [2] Isfahan University of Medical Sciences

     Isfahan University of Medical Sciences

     Irán

     
• Localización: Psicológica: Revista de metodología y psicología experimental, ISSN-e 1576-8597, ISSN 0211-2159, Vol. 34, Nº 2, 2013, págs. 273-284
• Idioma: inglés
• Enlaces
  • Texto completo (pdf)
• Resumen

  • In the present study, the effectiveness of 3 drug regimen on cognitive performance of PD patients was compared. 12 patients who had been using pramipexole, levodopa and amantadine for at least 1 month entered the study and compared with those 12 who had been using trihexiphenidyle, levodopa and amantadine. There was also a control group including 11 patients who had been using only levodopa and amantadine. All 3 groups were asked to answer Montreal Cognitive Assessment in pretest phase. Then patients in experimental groups were asked not to use pramipexole or trihexiphenidyle for 72 hours and then all 3 groups were asked to answer the same questionnaire in post test phase. The results showed that patients who have used pramipexole had better performance in executive functions in post test. The findings suggest that pramipexole in combination with levodopa and amantadine may worsen the executive function in Parkinson’s disease;

    however, there is almost neither adverse nor beneficial effect of trihexiphenidyl in such a combination on cognition in PD patients.

• Referencias bibliográficas
  • Athilingam, P.(2007). Validation of an Instrument to Measure Cognitive Function in Patients with Heartl Failure. Unpublished Doctoral Dissertation....
  • Bassett, S. S. (2005). Cognitive impairment in parkinson disease. Primary Psychiatry, 12 (7), 50-55
  • Beck, A. T., Epstein, N., Brown, G., & Steer, R. A. (1988). An inventory for measuring clinical anxiety. Psychometric properties. Journal...
  • Bosboom, J. W., Stoffers, D., & Wolters, E. C. (2004). Cognitive dysfunction and dementia in Parkinson's disease. Journal of Neural...
  • Brusa, L., Bassi, A. Stefani, A. Pierantozzi, M. Peppe, A. Caramia, M.D, and et al. (2003). Pramipexole in comparison to l-dopa: A neuropsychological...
  • Brusa, L., Tiraboschi, P., Koch, G., Peppe, A., Pierantozzi, M., Ruggieri, S., & Stanzione, P. (2005). Pergolide effect on cognitive functions...
  • Campbell, N. L., Boustani, M. A., Lane, K. A., Gao, S., Hendrie, H., Khan, B. A., et al. (2010). Use of anticholinergics and the risk of cognitive...
  • Caviness, J.N., Driver-Dunckley, E., Connor, D.J., Sabbagh, M.N., Hentz, J.G., Noble, B., et al. (2007). Defining Mild Cognitive Impairment...
  • Cooper, J. A., Harvey, J. S., Nigel, J., Norman, S. H., Sullivan, E. V. (1991). Cognitive impairment in early untreated parkinson's disease...
  • Dcamp, E., & Schneider, J. S. (2009). Interaction between nicotinic and dopaminergic therapies on cognition in a chronic Parkinson model....
  • De Letter, M., Van Borsel, J., & Santens, P. (2012). An electrophysiological investigation of the effects of levodopa on semantic comprehension...
  • Drag, L. L., Wright, S. L., & Bieliauskas, L. A. (2010). Prescribing Practices of Anticholinergic Medications and Their Association With...
  • Ehrt, U., Broich, K., Larsen, J. P., Ballard, C., & Aarsland, D. (2010). Use of drugs with anticholinergic effect and impact on cognition...
  • Emsaki, G., Molavi, H., Chitsaz, A., & Asgari, K. (2011). Psychometric Properties of the Montreal Cognitive Assessment (MoCA) in Parkinson's...
  • Gill, D. J., Freshman, A., Blender, J. A., & Ravina, B. (2008). The montreal cognitive assessment as a screening tool for cognitive impairment...
  • Goetz, C. G., Poewe, W., Rascol, O., Sampaio, C., Stebbins, G.T., Counsell, C., et. al. (2003). The Unified Parkinson's Disease Rating...
  • Graham, C. F., MacAskill, M.R. Dalrymple-Alford, J. C. L. Livingston, L. & Anderson, T. J. (2009). The effects of amantadine on memory...
  • Hamidovic, A., Kang J. U., and Wit, H. D. (2008). Effects of low to moderate acute doses of pramipexole on impulsivity and cognition in healthy...
  • Jankovic, J. (2008). Parkinson's disease: clinical features and diagnosis. Journal of Neurology, Neurosurgery and Psychiatry, 79, 368-376.
  • Kobayashi, Y, Hozumi, A., Tanaka, H., Arai, M., & Hirata, K. (2004). The efficacy of the levodopa on cognitive function in patients with...
  • Koerts, J., Leenders, K. L., and Brouwer, W. H. (2009). Cognitive dysfunction in non-demented Parkinson's disease patients: Controlled...
  • Konishi, K., Hori, K., Uchida, H., Watanabe, K., Tominaga, I., Kimura, M., et al. (2010). Adverse effects of anticholinergic activity on cognitive...
  • Lees, A. J., Smith, E. (1983). Cognitive deficits in the early stages of Parkinson's disease. Brain, 106, 257-270.
  • Leh, E. S., Petrides, M., & Strafella, A. P. (2010). The neural circuitry of executive functions in healthy subjects and parkinson's...
  • Levin, B.E., & Katzen, H.L. (1995). Early cognitive changes and nondementing behavioral abnormalities in Parkinson's disease. Advances...
  • Levin, O. S., Nesterova, O. S., Otcheskaia, O. V., Zhuravleva, E., Artemova, I., Khozova, A. A., Ismailov, A. M., Lisenker, L. N., Vdovichenko,...
  • Marnat, G. G. (2009). Handbook of Psychological Assessment. New Jersy: John Wiley and Sons.
  • Martin, M. A., Orsillo, M. S., and Roemer, L. (2001). Practitioner's Guide to Empirically Based Measures of Anxiety. NewYork: Plenum Publishers.
  • Nasreddine, Z. S., Phillips, N. A., Bedirian, V., Charbonneau, S., Whitehead, V., Collin, I., et al. (2005). The Montreal Cognitive Assessment,...
  • Owen, A. M. (2004). Cognitive Dysfunction in Parkinson's Disease: The Role of Frontostriatal Circuitry. Journal of Neurosciences, 10(3),...
  • Pagonabarraga, J., Kulisevsky, J., Llebaria, G., Sánchez, C.G., Pascual-Sedano, B., and Gironell, A. (2008). Parkinson's Disease-Cognitive...
  • Rowe, J. B., Hughes, B., Ghosh, B. C., Williams-Gray, C. H., Fallon, S., Barker, R. A., & Owen, A. M. (2008). Parkinson's disease...
  • Saletu, B., Anderer, P., Semlitsch, H. V., Grünberger, J., Linzmayer, L., Chaudhry, H. R. (1992). Amantadine infusions in mild dementia: acute...
  • Sanchez-Castaneda, C., Campdelacreu, J., Miro, J., Juncadella, M., Jauma, S., Calopa, M. (2010). Cognitive improvement after duodenal levodopa...
  • Sawamoto, N., Piccini, P., Hotton, G., Pavese, N., Thielemans, K., and Brooks, D. J. (2008). Cognitive deficits and striato-frontal dopamine...
  • Sharma, N. (2008). Parkinson's Disease. CT.: Greenwood press
  • Shaver, R. P., and Brennan, K. A. (1991). Measures of Personality and Social Psychological Attitudes.Volume 1. San Diego, California: Elsevier.
  • Siderowf, A., McDermott, M., Kieburtz, K., et al. (2002). Test-retest reliabilityof the UPDRS in patients with early Parkinson's disease:...
  • Smith, T., Gildeh, N., and Holmes, C. (2007). The Montreal Cognitive Assessment:Validity and Utility in a Memory Clinic Setting. The Canadian...
  • Sollinger, B. A., Goldstein, F.C., Lah, J. J., Levey, A. I., and Factor, S.A. (2010). Mild cognitive impairment in Parkinson's disease:...
  • Starkstein, S. E., & Merello, M. (2004). Psychiatric and Cognitive Disorders in Parkinson's Disease. Cambridge: Cambridge University...
  • William-Gray, C. H., Foltyne, T., Brayne, C. G., Robbins, T. W., Barker, R. A. (2007). Evolution of cognitive dysfunction in an incident parkinson's...
  • Wilson, K. A., Chambless, L. D., and Beurs, E. (2004). The Use of Psychological Testing for Treatment Planning and Outcomes Assessment. New...
  • Wittich, W., Phillips, N., Nasreddine, Z. N., and Chertkow, H.(2010). Sensitivity and Specificity of the Montreal Cognitive Assessment Modified...
  • Wong, A., Xiong, Y. Y. Kwan, P. W. Chan, A. Y. Lam, W. M. Wang, K. et al. (2009). The Validity, Reliability and Clinical Utility of the Hong...
  • York, M. K. & Alvarez, J. A. (2008). Cognitive impairments associated with parkinson's disease. In Trail, M., Protas, E. J., &...
  • Zadikoff, C., Fox, S. H., Tang-Wai, D. F., Thomsen, T., de Bie, R. M., Wadia, P., Miyasaki, J., Duff-Canning, S., Lang, A. E., & Marras,...