Genetic association study within the framework of Zuckerman's psychobiological personality model

• Luis F. García ^[1] ; Anton Aluja ^[3] ; Oscar García ^[3] ; Lara Cuevas ^[2]
  1. [1] Universidad Autónoma de Madrid

     Universidad Autónoma de Madrid

     Madrid, España

     
  2. [2] Universidad Complutense de Madrid

     Universidad Complutense de Madrid

     Madrid, España

     
  3. [3] Institut of Biomedical Research of Lleida, España

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• Localización: Anuario de psicología, ISSN 0066-5126, Vol. 46, Nº. 1 (Enero - Abril 2016 ), 2016, págs. 17-30
• Idioma: inglés
• DOI: 10.1016/j.anpsic.2016.06.003
• Títulos paralelos:
  • El estudio de la asociación genética dentro del modelo psicobiológico de personalidad de Zuckerman
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• Dialnet Métricas: 1 Cita
• Resumen
  • español

    Partiendo del modelo de personalidad psicobiológico de Zuckerman se planean una serie de hipótesis de la asociación genética de diferentes polimorfismos de la serotonina, testosterona, dopamina, MAO-A y COMT, y tres rasgos temperamentales (Búsqueda impulsiva de sensaciones no socializada, Neuroticismo y Extroversión-sociabilidad). Para superar limitaciones anteriores de este tipo de estudios: 1) la medida fenotípica se mejoró usando ocho escalas para medir los constructos de personalidad, y 2) algunos análisis estadísticos fueron usados para estudiar conjuntamente los efectos de los polimorfismos. La muestra analizada se compuso de 252 participantes de dos muestras de hombres, una de 147 presos y otra de 105 voluntarios sanos. Los resultados informan que cuando se consideran conjuntamente todos los polimorfismos estu-diados se observa una tendencia en la dirección de las hipótesis formuladas. La sección de la discusión recomienda aplicar variables más integradoras para explorar los caminos complejos de las genéticas a la conducta.

  • English

    Following Zuckerman's psychobiological personality model, a series of genetic association hypotheses between some polymorphisms of Serotonin, Testosterone, Dopamine, MAO-A and COMT, and three temperamental traits (Impulsive Unsocialized Sensation Seeking, Neuroticism, and Extroversion-Sociability) were tested. In order to surpass previous limitations of this kind of studies: 1) the measurement of the phenotype was improved by using eight personality scales, and 2) some statistical analyses were conducted to test conjointly the effects of the considered polymorphisms. 252 participants from two samples (147 male inmates, and 105 male healthy volunteers) were analyzed. A tendency in the theoretical expected direction is reported when several polymorphisms are considered conjointly. The discussion section recommends applying more integrative frameworks to explore the complex paths from genetics to behavior.

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