Acceso usuarios
Kaitlin A. Hagan, Tianying Wu, A.Heather Eliassen, Olivia I. Okereke
Background and Objectives:
Psychological distress has been hypothe- sized to be associated with adverse biologic states such as higher oxidative stress and in- flammation. Yet, little is known about associations between a common form of distress –phobic anxiety– and global oxidative stress. Thus, we related phobic anxiety to plasma fluorescent oxidation products (FlOPs), a global oxidative stress marker.
Methods:
We conducted a cross-sectional analysis among 1,325 women (aged 43-70 years) from the Nurses’ Health Study. Phobic anxiety was measured using the Crown-Crisp Index (CCI). Adjusted least-squares mean log-transformed FlOPs were calculated across phobic categories. Logistic regression models were used to calculate odds ratios (OR) com- paring the highest CCI category ( ≥ 6 points) vs. lower scores, across FlOPs quartiles.
Results : No association was found between phobic anxiety categories and mean FlOP levels in multivariable adjusted linear models. Similarly, in multivariable logistic regres- sion models there were no associations between FlOPs quartiles and likelihood of being in the highest phobic category. Comparing women in the highest vs. lowest FlOPs quartiles:
FlOP_360: OR = 0.68 (95% CI: 0.40 – 1.15); FlOP_320: OR = 0.99 (95% CI: 0.61 – 1.61);
FlOP_400: OR = 0.92 (95% CI: 0.52, 1.63).
Conclusions:
No cross-sectional association was found between phobic anxiety and a plasma measure of global oxidative stress in this sample of middle-aged and older women
Anxiety; Biochemical markers; Biologi- cal psychiatry; Oxidative Stress; Phobic Anxiety
