Effects of psychological stress and housing conditions on the delay of wound healing

• Autores: Óscar Vegas Moreno, JoAnne VanBuskirk, Steven Richardson, David Parfitt, Dana Helmreich, Max Rempel, Jan Moynihan, Francisco Tausk
• Localización: Psicothema, ISSN-e 1886-144X, ISSN 0214-9915, Vol. 24, Nº. 4, 2012, págs. 581-586
• Idioma: inglés
• Títulos paralelos:
  • Efectos del estrés psicológico y de las condiciones de alojamiento en el retraso en la cicatrización de heridas
• Enlaces
  • Texto completo (pdf)
• Dialnet Métricas: 1 Cita
• Resumen
  • español

    Este trabajo explora los efectos del estrés y de las condiciones de alojamiento, en el proceso de cicatrización de heridas cutáneas, y su relación con los niveles de corticosterona circulante. Concretamente, proponemos examinar el efecto combinado de estresores físicos (estrés por inmovilización y ultrasonidos) y psicológicos (olor de un depredador), en la cicatrización de heridas cutáneas en ratones hembras alojados en grupo (con apoyo social; n= 16) o individualmente (sin apoyo social; n= 16). Frente a otros estudios, el modelo etológico de estresores medios múltiples utilizado en este trabajo incrementó los niveles de corticosterona, pero no alteró de manera significativa el proceso de cicatrización de las heridas en la piel. Sin embargo, los resultados de este estudio muestran la importancia de las condiciones de alojamiento, sugiriendo que las interacciones sociales positivas en hembras aceleran el proceso de cicatrización de las heridas y reducen los niveles de ansiedad y de corticosterona circulante. Tanto el nivel de ansiedad como los niveles de corticosterona basal mostraron ser predictores válidos del nivel de cicatrización en diferentes momentos del proceso de curación de heridas cutáneas.

  • English

    This study explores the effects of stress and housing conditions on the healing of cutaneous wounds and its relationship with circulating levels of corticosterone. Specifically, we set out to examine the effect of combined physical (restraint stress and ultrasound) and psychological (predator scent) stressors on the cutaneous wound healing of female mice that had been housed either in groups (with social support; n= 16) or individually (without social support; n= 16). In contrast with other studies, the model of multiple ethological mild stressors utilized in this study significantly increased the levels of corticosterone, but failed to dramatically alter the healing of skin wounds. However, the results of this study provide evidence of the importance of housing conditions, suggesting that positive social interactions in females accelerate the rate of wound healing, and reduce levels of anxiety and circulating corticosterone. The level of anxiety, as well as the basal levels of corticosterone, proved to be valid predictors of the healing rates during different stages of cutaneous wound healing

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