Previous research indicates that increases in positive affect enhance personal resources and bring about improvements in various realms of life. The present study examined the role of general self-efficacy as a mediator between increases in positive affect and change in work and relationship satisfaction and mental health. Participants randomly assigned to a three-week intervention intended to increase positive affect showed significantly greater change in positive affect, ratio of positive to negative affect, self-efficacy, work satisfaction and mental health than participants in a control condition. Changes in affect were associated with changes in self-efficacy, work satisfaction, relationship satisfaction and mental health. Changes in self-efficacy were associated with increases in work satisfaction and mental health. The findings incorporate the concept of general self-efficacy into the broaden and build model and provide information regarding the utility of ratio of positive to negative affect indices.