Transferring one's knowledge in new situations is usually associated with cognitively demanding processes. The paper explores an approach to facilitating transfer of knowledge by explicitly instructing learners in medium-level generalized but yet domain-connected knowledge structures that are applicable to a broader range of tasks in the domain and could be essential in managing the cognitive load associated with transfer. The paper includes a theoretical analysis of the potential role of the generalized domain knowledge in transfer and an experimental study designed to investigate the effectiveness of explicit instruction in a generalized domain knowledge structure (function--process--structure schema) in technical areas. Forty-nine undergraduate university students with low or no prior knowledge in the domain participated in the randomised 2 (schema-based vs. non-schema-based instruction)×2 (general-to-specific vs. specific-to-general knowledge sequences) experiment investigating the effects of these two factors on posttest transfer performance and subjective ratings of learning difficulty (interpreted as indicators of cognitive load). The results indicated a significant (p<0.05) main effect of schema-based instruction; a possible trend (p<0.1) favouring general-to-specific instructional sequence for posttest test performance; and a significant interaction between the two factors for ratings of difficulty. The paper concludes that (a) transfer within a domain could be facilitated by explicitly instructing learners in generalized domain schemas; (b) general-to-specific approach could possibly be used as a preferred instructional sequence for enhancing transfer; and (c) cognitive load perspective could add some valid arguments to explain the role of generalized domain knowledge in transfer.