El uso del modelo farmacológico basado en la administración experimental de MK-801, para la revisión y re-definición del sistema límbico en el contexto de la anátomo-patología

• Autores: Adrián Marcelo Bueno, Soledad de Olmos
• Localización: Ciencias Psicológicas, ISSN 1688-4094, ISSN-e 1688-4221, Año 3, Nº. 1, 2009, págs. 83-90
• Idioma: español
• DOI: 10.22235/cp.v3i1.140
• Títulos paralelos:
  • The use of the pharmacological model based on the experimental administration of mk-801, for the revision and redefinition of the limbic system into the anatomical and pathological context
• Enlaces
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• Resumen
  • español

    El efecto neurotóxico inducido en el sistema límbico de ratas por el tratamiento agudo con MK-801, afecta a todas las áreas del lóbulo límbico, como la corteza olfatoria, la amígdala baso-lateral, el sistema hipocampal, la corteza del cíngulo y regiones especí fi cas de la corteza frontal e insular (allo- corticales y meso-corticales). En contraste, los núcleos sub-corticales habitualmente incluidos en el sistema límbico, como la amígdala extendida, el sistema estriado-palidal ventral, el área septal, el tálamo y el hipotálamo, no evidencian muerte neuronal. Los resultados anátomo-patológicos sugieren que las áreas del lóbulo límbico comparten características comunes, y soporta la idea de una unidad funcional que es diferente, dentro del sistema límbico, de otras regiones “límbicas” sub-corticales. Esto apoya la consideración de un lóbulo límbico compuesto estrictamente por áreas allo-corticales y meso-corticales del telencéfalo e implica la necesidad de re-de fi nir el clásico y amplio concepto de “sistema límbico”.

  • English

    The neuro-toxic effect induced in the rat limbic system after acute MK-801-treatment, affects all the limbic lobe areas, such as olfactory cortex, basolateral amygdala, hippocampal system, cingulate cortex and speci fi c frontal and insular cortical region (allo-cortical and meso-cortical areas). In contrast, the sub-cortical nucleus usually included into the limbic system, such as the extended amygdala, the estriato-pallidal-ventral system, septal area, thalamus and hippothalamus, do not evidentiate neural dea- th. Anatomo-pathological results suggest that the limbic lobe areas share common characteristics, and support the idea of a different functional unit, which differs from other sub-cortical “limbic” regions.

    This supports the idea of a limbic lobe formed only by thelencephalic allo-cortical and meso-cortical areas and implies the need to rede fi ne the classic and broad concept of “limbic system”.

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