The aims of the present study were to examinate the correlation between depression and familiar conflicts in adolescents who live in rural or urban communities in Tlaxcala, and to identify differences in the degree of adolescents´ depression according to their gender, as well as in accordance with the type of community (urban or rural) in which they live. The Family Environment Scale (FES) and the Beck Depression Inventory (BDI) were used to evaluate 342 participants with a mean age of 13.4 years. Analysis of data was accomplished by Pearson`s correlation coefficient and variance analysis ANOVA. Results show that depression was found to be negatively related to the family cohesion. Also, based in the ANOVA, results show that only the effects of relation were significant.