Resumen de Orbitofrontal Cortex inactivation impairs early reversal learning in male rats during a sexually motivated task

Miguel Ángel Guevara Pérez, Francisco Abelardo Robles Aguirre, Gina L. Quirarte, Marisela Hernández González

• This study analyzes whether inactivation of the orbitofrontal cortex (OFC) affects early discrimination or reversal learning during a T maze motivated task. Male rats received saline solution or one doses of tetrodotoxin (TTX) bilaterally into the OFC, and were permitted to have an intromission with a receptive female to induce a sexually motivated state. Discrimination and reversal sessions consisted of seven trials each to accomplish the non-overtrained condition.

  Each arm of the T maze was associated to different external cues. Subjects were sexually reinforced whenever they reached the receptive female box, and returned to the start-box if not. Spontaneous motor activity was not altered. Rats with OFC inactivated did not present alteration during discrimination. Males with higher doses of TTX had a deficit in the number of correct responses and increased number of trials without response during reversal learning.

  These data agrees with other studies and indicates that an intact OFC is essential for the adequate manifestation of reversal learning during its early phase in motivated tasks. However, disagrees with other findings about early perseverative responses, pointing out to a critical role of this structure in enhancing performance through incentive value re-assignment of predicted outcome cues.