Efectos del haloperidol sobre la catalepsia en ratones macho

• Autores: Antonio L. Muñoz, José Francisco Navarro Humanes, Vicente M. Simón Pérez, María Teresa Rivas Moya, José Miñarro López
• Localización: Psicothema, ISSN-e 1886-144X, ISSN 0214-9915, Vol. 4, Nº. 2, 1992, págs. 369-377
• Idioma: español
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• Resumen

  • En el presente trabajo se estudia la catalepsia inducida por haloperidol en ratones macho. Para la evaluación de la catalepsia se utilizó el test de la barra. Se efectuó una única administración i.p. de haloperidol (0.4, 0.7 y 1 mg/kg) o suero salino (CINa al 0.9 %) con evaluaciones sucesivas a los 35 y 120 minutos de la inyección. Los resultados indicaron un claro efecto dependiente de la dosis. A los diez días de la primera inyección se efectuó una segunda administración a fin de detectar posibles efectos sensibilizadores realizando igualmente dos mediciones sucesivas como en el primer caso. No se apreciaron, para ninguna de las dosis, efectos sensibilizadores del fármaco en esta segunda administración. En ningún caso se apreciaron diferencias significativas entre la evaluación realizada a los 35 y la realizada a los 120 minutos.

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