Memoria espacial y expresión de c-fos en núcleo supramamilar, giro cingulado anterior y corteza entorrinal

• Sandra María Rubio Fernández ^[1] ; Azucena Begega Losa ^[1] ; Luis Javier Santín Núñez ; José A. Aguirre ; Jorge Luis Arias Pérez ^[1] ; Rubén Miranda ^[1]
  1. [1] Universidad de Oviedo

     Universidad de Oviedo

     Oviedo, España

     
• Localización: Psicothema, ISSN-e 1886-144X, ISSN 0214-9915, Vol. 13, Nº. 2, 2001, págs. 214-221
• Idioma: español
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• Resumen

  • Memoria espacial y expresión de c-fos en núcleo supramamilar, giro cingulado anterior y corteza entorrinal. Este trabajo se aproxima al estudio de los substratos cerebrales de la memoria espacial en ratas, empleando la expresión celular de la proteína c-Fos. Para ello, se analizó la expresión de la proteína c-Fos después de la ejecución de una tarea de memoria de referencia y otra de trabajo espacial. De este modo, se cuantificó el número de núcleos neuronales c-Fos positivos en varias regiones cerebrales: corteza entorrinal, giro cingulado anterior y núcleo supramamilar. Los resultados mostraron que el entrenamiento espacial en tareas de memoria, incrementa el número de neuronas activadas en la corteza entorrinal (neuronas c-Fos positivas). No se halló una relación clara entre la activación c-fos en el giro cingulado anterior y las demandas de memoria de las tareas. El número de núcleos neuronales c-Fos positivos en las neuronas del núcleo supramamilar, fue mayor en los grupos de memoria de trabajo que en los grupos de memoria de referencia, sugiriendo que las neuronas de este núcleo desempeñan un papel importante en el procesamiento espacial.

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