Psychological flexibility is a transdiagnostic construct associated with psychological well-being and academic success. The Acceptance and Action Questionnaire for University Students (AAQ-US) is a tool designed to measure psychological inflexibility i n e ducational c ontexts. This s tudy a imed to evaluate the psychometric properties of the AAQ-US in Mexican university students. The research comprised a sample of 959 Mexican university students who completed the AAQ-US and measures of psychological inflexibility, emotional symptoms, academic self-efficacy, and academic burnout. The AAQ-US demonstrated excellent internal consistency. Factor analyses supported a unidimensional structure, consistent with the original instrument. Measurement invariance was established across gender, university sector, prior mental health care, and levels of emotional symptoms. The AAQ-US showed the expected correlations with related constructs and discriminated between groups with and without elevated emotional symptoms. The Mexican adaptation of the AAQ-US demonstrates strong psychometric properties to assess psychological inflexibility i n a cademic contexts a mong Mexican university students