Cardiovascular Health, Assessed by Life’s Essential 8, Is Associated with Lower Risk of Disability Among Older, Community-Dwelling Men and Women

• Xin Li ^[1] ; Yichen Jin ^[1] ; Stefania Bandinelli ; Luigi Ferrucci ; Toshiko Tanaka ; Sameera A. Talegawkar ^[1]
  1. [1] George Washington University

     George Washington University

     Estados Unidos

     
• Localización: EJIHPE: European Journal of Investigation in Health, Psychology and Education, ISSN 2174-8144, ISSN-e 2254-9625, Vol. 15, Nº. 9, 2025, págs. 181-181
• Idioma: inglés
• DOI: 10.3390/ejihpe15090181
• Enlaces
  • Texto completo
• Resumen

  • Our study examined the associations between overall cardiovascular health (CVH) and the risk of disability in older adults over 16 years of follow-up. Data from the InCHIANTI study were used and included 928 participants aged 65 years and older. Overall CVH was measured using the “Life’s Essential 8” (LE8) metric. Disability status was assessed by the Activities of Daily Living (ADL) and the Instrumental Activities of Daily Living (IADL). Higher overall LE8 score at baseline was associated with lower risks of having the first ADL among males (hazard ratio [HR] = 0.66, p = 0.001) and IADL disability event (HR = 0.89, p = 0.016) using the Cox proportional hazards model. Higher LE8 scores were also associated with ADL (odds ratio [OR] (females) = 0.80, p = 0.034; OR (males) = 0.55, p < 0.001) and IADL worsening (OR = 0.72, p < 0.001) using Generalized Estimating Equation models. Among older adults, better CVH assessed by the LE8 metric was associated with lower risk of ADL and IADL disabilities and their worsening over time. These findings underscore the importance of promoting CVH as a key strategy to support healthy aging and reduce disability burden. Public health interventions that target CVH components may be effective in preserving functional independence among older populations.

• Referencias bibliográficas
  • Alonzo, E., Bonaccorsi, G., Cairella, G., Carreri, V., Guberti, E., Nucci, D., Panunzio, M. F., & Valerio, E. (2023). The “nutritional...
  • Barbabella, F., Cela, E., Socci, M., Lucantoni, D., Zannella, M., & Principi, A. (2022). Active ageing in Italy: A systematic review of...
  • Bartali, B., Turrini, A., Salvini, S., Lauretani, F., Russo, C. R., Corsi, A. M., Bandinelli, S., D’Amicis, A., Palli, D., Guralnik, J. M.,...
  • Boccardi, V., & Mecocci, P. (2023). Intermediate care in Italy: Addressing the challenges and opportunities for person-tailored care....
  • Bock, J. M., Vungarala, S., Covassin, N., & Somers, V. K. (2022). Sleep duration and hypertension: Epidemiological evidence and underlying...
  • Borda, M. G., Venegas-Sanabria, L. C., Garcia-Cifuentes, E., Gomez, R. C., Cano-Gutierrez, C. A., Tovar-Rios, D. A., Aarsland, V., Khalifa,...
  • Burt, V. L., Whelton, P., Roccella, E. J., Brown, C., Cutler, J. A., Higgins, M., Horan, M. J., & Labarthe, D. (1995). Prevalence of hypertension...
  • Chen, M., Chen, Y., & Li, C. (2024). Life’s Essential 8 and its association with osteoarthritis and disability: A cross-sectional study...
  • Chernew, M. E., Goldman, D. P., Pan, F., & Shang, B. (2005). Disability and health care spending among medicare beneficiaries. Health...
  • Corona, L. P., Pereira de Brito, T. R., Nunes, D. P., da Silva Alexandre, T., Ferreira Santos, J. L., de Oliveira Duarte, Y. A., & Lebrão,...
  • Cui, K., Song, R., Xu, H., Shang, Y., Qi, X., Buchman, A. S., Bennett, D. A., & Xu, W. (2020). Association of cardiovascular risk burden...
  • Dashti, H. S., Scheer, F. A., Jacques, P. F., Lamon-Fava, S., & Ordovás, J. M. (2015). Short sleep duration and dietary intake: Epidemiologic...
  • Devulapalli, S., Shoirah, H., & Dhamoon, M. S. (2016). Ideal cardiovascular health metrics are associated with disability independently...
  • Dick, J. P., Guiloff, R. J., Stewart, A., Blackstock, J., Bielawska, C., Paul, E. A., & Marsden, C. D. (1984). Mini-mental state examination...
  • EU SHD Coalition. (2024, October 29). Press release: Approval of resolutions for the Italian national cardiovascular and cerebrovascular diseases...
  • Ferrucci, L., Bandinelli, S., Benvenuti, E., Di Iorio, A., Macchi, C., Harris, T. B., & Guralnik, J. M. (2000). Subsystems contributing...
  • Fried, L. P., Ferrucci, L., Darer, J., Williamson, J. D., & Anderson, G. (2004). Untangling the concepts of disability, frailty, and comorbidity:...
  • Fried, L. P., & Guralnik, J. M. (1997). Disability in older adults: Evidence regarding significance, etiology, and risk. Journal of the...
  • García-Hermoso, A., Ramírez-Vélez, R., Ramirez-Campillo, R., & Izquierdo, M. (2017). Relationship between ideal cardiovascular health...
  • Grandner, M. A., Seixas, A., Shetty, S., & Shenoy, S. (2016). Sleep duration and diabetes risk: Population trends and potential mechanisms....
  • Hajjar, I., Lackland, D. T., Cupples, L. A., & Lipsitz, L. A. (2007). Association between concurrent and remote blood pressure and disability...
  • Hasbani, N. R., Ligthart, S., Brown, M. R., Heath, A. S., Bebo, A., Ashley, K. E., Boerwinkle, E., Morrison, A. C., Folsom, A. R., Aguilar,...
  • Heiland, E. G., Welmer, A. K., Wang, R., Santoni, G., Fratiglioni, L., & Qiu, C. (2019). Cardiovascular risk factors and the risk of disability...
  • Heller, B., Reiter, F. P., Leicht, H. B., Fiessler, C., Bergheim, I., Heuschmann, P. U., Geier, A., & Rau, M. (2023). Salt-intake-related...
  • Idalino, S. C. C., Cândido, L. M., Wagner, K. J. P., de Souza Moreira, B., de Carvalho Bastone, A., Danielewicz, A. L., & de Avelar, N....
  • Imai, K., Gregg, E. W., Chen, Y. J., Zhang, P., de Rekeneire, N., & Williamson, D. F. (2008). The association of BMI with functional status...
  • ISTAT. (2022). Popolazione Italiana residente al 1° Gennaio, 2022. ISTAT Geodemo.
  • Jin, Y., Tanaka, T., Ma, Y., Bandinelli, S., Ferrucci, L., & Talegawkar, S. A. (2019). Cardiovascular health is associated with disability...
  • Katz, S., Ford, A. B., Moskowitz, R. W., Jackson, B. A., & Jaffe, M. W. (1963). Studies of illness in the aged. The index of ADL: A standardized...
  • Khoury, S., Yarows, S. A., O’Brien, T. K., & Sowers, J. R. (1992). Ambulatory blood pressure monitoring in a nonacademic setting. Effects...
  • Lafferty, M. E., Fried, L. P., Simonsick, E. M., Kasper, J. D., & Guralnik, J. M. (1996). The women’s health and aging study: Health and...
  • Lawton, M. P., & Brody, E. M. (1969). Assessment of older people: Self-maintaining and instrumental activities of daily living. Gerontologist,...
  • Lee, Y. S. (2005). Gender differences in physical activity and walking among older adults. Journal of Women & Aging, 17(1–2), 55–70.
  • Lloyd-Jones, D. M., Allen, N. B., Anderson, C. A. M., Black, T., Brewer, L. C., Foraker, R. E., Grandner, M. A., Lavretsky, H., Perak, A....
  • Lloyd-Jones, D. M., Hong, Y., Labarthe, D., Mozaffarian, D., Appel, L. J., Van Horn, L., Greenlund, K., Daniels, S., Nichol, G., Tomaselli,...
  • Makarem, N., Castro-Diehl, C., St-Onge, M. P., Redline, S., Shea, S., Lloyd-Jones, D., Ning, H., & Aggarwal, B. (2022). Redefining cardiovascular...
  • Melchiorre, M. G., Socci, M., Quattrini, S., Lamura, G., & D’Amen, B. (2022). Frail older people ageing in place in Italy: Use of health...
  • Milaneschi, Y., Bandinelli, S., Penninx, B. W., Vogelzangs, N., Corsi, A. M., Lauretani, F., Kisialiou, A., Vazzana, R., Terracciano, A.,...
  • Nakakubo, S., Doi, T., Makizako, H., Tsutsumimoto, K., Hotta, R., Ono, R., Suzuki, T., & Shimada, H. (2016). Sleep duration and excessive...
  • Panico, S., Palmieri, L., Donfrancesco, C., Vanuzzo, D., Chiodini, P., Cesana, G., Ferrario, M., Mattiello, A., Pilotto, L., Sega, R., &...
  • Plichart, M., Barberger-Gateau, P., Tzourio, C., Amouyel, P., Pérès, K., Ritchie, K., Jouven, X., Ducimetière, P., & Empana, J. P. (2010)....
  • Rowe, J. W., & Kahn, R. L. (1997). Successful aging. Gerontologist, 37(4), 433–440.
  • Su, P., Ding, H., Zhang, W., Duan, G., Yang, Y., Long, J., Du, L., Xie, C., Jin, C., Hu, C., & Tian, W. (2017). Joint association of obesity...
  • Van Eeuwijk, P., & Angehrn, Z. (2017). How to… conduct a focus group discussion (FGD). Methodological manual. University of Basel.
  • Wiinberg, N., Høegholm, A., Christensen, H. R., Bang, L. E., Mikkelsen, K. L., Nielsen, P. E., Svendsen, T. L., Kampmann, J. P., Madsen, N....
  • Wilby, M. L. (2019). Physical mobility impairment and risk for cardiovascular disease. Health Equity, 3(1), 527–531.
  • Zhang, L., Ukawa, S., Zhao, W., Okabayashi, S., Ando, M., Wakai, K., Tsushita, K., Kawamura, T., & Tamakoshi, A. (2019). Daily sleep duration...