Efectos del consumo de café para la salud cardiovascular, la diabetes y el desarrollo del cáncer

• Autores: José Luis Blanco Coronado, Emilio Moreno San Pedro, Jesús Gil Roales-Nieto, Ana Gil Luciano
• Localización: Psicothema, ISSN-e 1886-144X, ISSN 0214-9915, Vol. 16, Nº. 4, 2004, págs. 531-547
• Idioma: español
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• Dialnet Métricas: 2 Citas
• Resumen
  • español

    Se revisan y analizan las relaciones entre consumo de café y riesgo para la salud en los tres grupos de trastornos primeras causas de muerte prematura: trastornos cardiovasculares, diabetes y cáncer. Se revisan los estudios epidemiológicos y experimentales existentes, y aquellos que han explorado los agentes o mecanismos responsables del efecto de riesgo o protector para la salud del consumo de café. Los resultados indican que existen evidencias de aumento del riesgo de trastornos cardiovasculares por consumo de café, mientras que los datos no son concluyentes respecto a las relaciones entre riesgo de diabetes y consumo. Las relaciones entre consumo de café y riesgo de cáncer parecen probables en el caso de los cánceres de páncreas y de ovario, mientras que el consumo de café se muestra como un factor protector del cáncer de colon y recto y los datos no son concluyentes para el cáncer de vejiga. En todos los casos se indican las hipótesis disponibles sobre mecanismos responsables del efecto y se señalan posibles formas de consumo saludable que reduzcan los riesgos

  • English

    Effects of coffee consume on cardiovascular health, diabetes and cancer. This paper presents a revision of the relationships between coffee consumption and health across the three groups of diseases that are the first causes of premature death: cardiovascular diseases, diabetes and cancer. Epidemiological and experimental studies show relative evidences of increasing cardiovascular risk correlated to coffee consumption while no clear relationship is found concerning diabetes. Relationships between coffee consumption and cancer risk are likely in the case of pancreas and ovarian cancers while coffee consumption appears as a protector factor in colorectal cancer with no concluding data in the case of bladder cancer. This paper also presents the available hypotheses concerning the mechanisms that might be responsible of coffee consumption as a risk or protector factor for the diseases revised, and healthy forms of coffee consumption that minimize risk are indicated

• Referencias bibliográficas
  • Abu-Zeid, H., Choi, N. y Hsu, P. (1981). Factors associated with risk of cancer of the colon and rectum. American Journal of Epidemiology,...
  • Ahola, I., Jauhiainen, M. y Aro, A. (1991). The hypercholesterolemic factor in boiled coffee is retained by a paper filter. Journal of Internal...
  • American Institute for Cancer Research. (1997). World Cancer Research Fund and American Institute for Cancer Research. Food, Nutrition and...
  • Arion, W., Canfield, W., Ramos, F. et al. (1997). Chlorogenic acid and hydrosynitrobenzaldehyde: new inhibitors of hepatic glucose-6-phosphatase....
  • Aro, A., Teirila, J. y Gref, C.G. (1990). Dose-dependent effect on serum cholesterol and apoprotein B concentrations by consumption of boiled,...
  • Aro, A., Tuomilehto, J., Kostiainen, E., Uusitalo, U. y Pietinen, P. (1987). Boiled coffee increases serum low density lipoprotein concentration....
  • Biaggioni, I. y Davis, S. (2002). Caffeine: A cause of insulin resistance? Diabetes Care, 25, 399-400.
  • Bjelke, E. (1974). Colon cancer and blood-cholesterol. Lancet, 1, 1.116-1.117.
  • Brown, C.A., Boltonsmith, C., Woodward, M. y Tunstallpedoe, H. (1993). Coffee and tea consumption and the prevalence of coronary heart-disease...
  • Byers, T., Marshall, J., Graham, S., Mettlin, C. y Swanson, M. (1983). A case-control study of dietary and nondietary factors in ovarian cancer....
  • Cavin, C., Bezencon, C., Guignard, G. y Schilter, B. (2003). Coffee diterpenes prevent benzo[a]pyrene genotoxicity in rat and human culture...
  • Christensen, B., Mosdol, A., Retterstol, L., Landaas, S. y Thelle, D. (2001). Abstention from filtred coffee reduce the concentrations of...
  • Christensen, L. y Murray, T. (1990). A review of the relationship between coffee consumption and coronary heart disease. Journal of Community...
  • Chyou, P., Nomura, A. y Stemmermann, G. (1993). A prospective study of diet, smoking and lowe urinary tract cancer. Annals of Epidemiology,...
  • Clifford, M. (2000). Chlorogenic acid and other cinnamates-nature, occurence, dietary burden, absorption and metabolism. Journal of Science...
  • Corti, R., Binggeli, C., Sudano, I., Spieker, L., Hänseler, E., Ruschitzka, F., Chaplin, W., Lüscher, T. y Noll, G. (2002). Coffee acutely...
  • Cramer, D. y Welch, W. (1983). Determinants of ovarian cancer risk. II. Inferences regarding pathogenesis. Journal of the National Cancer...
  • Cramer, D., Welch, W., Hutchison, G. y Willett, W. (1984). Dietary animal fat in relation to ovarian cancer risk. Obstetrics and Gynecology,...
  • Crist, G., Xu, B., LaNoue, K. y Lang, C. (1998). Tissue-specific effects of in vivo adenosine receptor blockade on glucose uptake in Zucker...
  • D’Amicis, A., Scaccini, C., Tomassi, G., Anaclerio, M., Stornelli, R. y Bernini, A. (1996). Italian style brewed coffee: effect on serum cholesterol...
  • Dales, L., Friedman, G., Ury, H. et al. (1979). A case-control study of relationships of diet and other traits to colorectal cancer in American...
  • deRoos, B. y Katan, M.B. (1999). Possible mechanisms underlying the cholesterol-raising effect of the coffee diterpene cafestol. Current Opinion...
  • deRoos, B., Vanderweg, G., Urgert, R., Vandebovenkamp, P., Charrier, A. y Katan, M. B. (1997). Levels of Cafestol, Kahweol, and related diterpenoids...
  • Donato, F., Boffetta, P., Fazioli, R., Aulenti, V., Gelatti, U. y Porru, S. (1997). Bladder cancer, tobacco smoking, coffee and alcohol drinking...
  • Escohotado, A. (1989). Historia de las drogas. Vol. 1. Madrid: Alianza Editorial.
  • Feinberg, L., Sandberg, H., De Castro, O. y Bellet, S. (1968). Effects of coffee ingestion on oral glucose tolerance curves in normal human...
  • Forde, O.H., Knutsen, S.F., Arnesen, E. y Thelle, D.S. (1985). The Tromso Heart Study: Coffee consumption and serum lipid concentrations in...
  • Franceschi, S. (1993). Coffee and myocardial infarction: review of epidemiological evidence. En S. Garattini (Ed.), Caffeine, Coffee, and...
  • Fried, R.E., Levine, D.M., Kwiterovich, P.O., Diamond, E.L., Wilder, L.B., Moy, T.F. y Pearson, T.A. (1992). The effect of filtered-coffee...
  • Gil Roales-Nieto, J. (1999). Manual de Psicología de la Salud. Volumen II. Comportamiento y salud/enfermedad. Granada: Ediciones Némesis.
  • Gil Roales-Nieto, J. (2004). Psicología de la Salud. Aproximación histórica, conceptual y aplicaciones. Madrid: Ediciones Pirámide.
  • Gil Roales-Nieto, J., López Ríos, F. y Moreno San Pedro, E. (2001). Evolución de las características del consumo de tabaco: un estudio transversal....
  • Gil Roales-Nieto, J., Moreno San Pedro, E. y Blanco Coronado, J. (2001). Niveles de colesterol y consumo de café: Cafefusión como forma de...
  • Giovannucci, E. (1998). Meta-analysis of coffee consumption and risk of colorectal cancer. American Journal of Epidemiology, 147, 1.043-1.052.
  • Greenland, S. (1993). A meta-analysis of coffee, myocardial infarction, and coronary death. Epidemiology, 4, 366-374.
  • Greer, F., Hudson, R., Ross, R. y Graham, T. (2001). Caffeine ingestion decreases glucose disposal during a hyperinsulinemic-euglycemic clamp...
  • Grobbee, D. E., Rimm, E. B., Giovanucci, E., Colditz, G., Stampfer, M. y Willett, W.C. (1990). Coffee, caffeine, and cardiovascular disease...
  • Gross, G., Jaccaud, E., y Huggett, A.C. (1997). Analysis of the content of the diterpenes Cafestol y Kahweol in coffee brews. Food and Chemical...
  • Grubben, M., Boers, G., Blom, H., Broekhuizen, R., de Jong, R., van Rijt, L., de Ruijter, E., Swinkels, D., Nagengast, F. y Katan, M. (2000)....
  • Harnack, L., Anderson, K., Zheng, W., Folsom, A., Sellers, T. y Kushi, L. (1997). Smoking, alcohol, coffee, and tea intake and incidence of...
  • Hartge, P., Lesher, L., McGowan, L. y Hoover, R. (1982). Coffee and ovarian cancer. International Journal of Cancer, 30, 531-532.
  • Hartley, T., Sung, B., Pincomb, G., Whitsett, T., Wilson, M. y Lovallo, W. (2000). Hypertension risk status and effect of caffeine on blood...
  • Hartman, T., Tangrea, J., Pictinin, P. et al. (1998). Tea and coffee consumption and risk of colon and rectal cancer in middle-aged Finnish...
  • Heckers, H., Gobel, U. y Kleppel, U. (1994). End of the coffee mystery-Diterpene alcohols raise serum low-density-lipoprotein cholesterol...
  • International Agency for Research on Cancer. (1991). IARC Monographs of the evaluation of carcinogenic risks to humans. Vol. 51. Coffee, tea,...
  • International Agency for Research on Cancer (1997). Coffee, tea, mate, methylxanthines and methylglyoxal. Lyon: IARC.
  • Isogawa, A., Noda, M., Takahashi, Y., Kadowaki, T. y Tsugane, S. (2003). Coffee consumption and risk of type 2 diabetes mellitus. Lancet,...
  • Jacobsen, B. (1987). Coffee, cholesterol, and colon cancer: is there a link? British Medical Journal, 294, 4-5.
  • Jacobsen, B. y Heuch, I. (2000). Coffee K-ras mutations and pancreatis cancer: A heterogeneous aetiology or an artefact? Journal of Epidemiology...
  • James, J. (1997). Is habitual caffeine use a preventable cardiovascular risk factor? Lancet, 349, 279-281.
  • Jankelson, O., Beaser, S., Howard, F. y Mayer, J. (1967). Effect of coffee on glucose tolerance and circulating insulin in men with maturity-onset...
  • Jansen, D.F., Nedeljkovic, S., Feskens, E.J., Ostojic, M.C., Grujic, M.Z., Bloemberg, B.P. y Kromhout, D. (1995). Coffee consumption, alcohol...
  • Jee, S., He, J., Whelton, P., Suh, I. y Klag, M. (1999). The effect of chronic coffee drinking on blood pressure. A meta-analysis of controlled...
  • Johnston, K., Clifford, M. y Morgan, L. (2003). Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans:...
  • Keijzers, G., De Galan, B., Tack, C. y Smits, P. (2002). Caffeine can decreased insulin sensitivity in humans. Diabetes Care, 25, 364-369.
  • Klag, M., Wang, N.Y., Meoni, L., Brancati, F., Cooper, L., Liang, K.Y., Young, J. y Ford, D. (2002). Coffee intake and risk of hypertension....
  • Kleemola, P., Jousilahti, P., Pietinen, P., Vartiainen, E. y Tuomilehto, J. (2000). Coffee consumption and the risk of coronary heart disease...
  • Knowler, W., Pettitt, D., Saad, M. y Bennett, P. (1990). Diabetes mellitus in the Pima Indians: incidence, risk factors and pathogenesis....
  • Kuper, H., Mucci, L. y Trichopoulos, D. (2000). Coffee, pancreatic cancer and the question of causation. Journal of Epidemiology and Community...
  • Kuper, H., Titus-Ernstoff, L., Harlow, B. y Cramer, D. (2000). Population based study of coffee, alcohol and tobacco use and risk of ovarian...
  • La Vecchia, C., Liati, P., Decarli, A., Negri, E. y Franceschi, S. (1987). Coffee consumption and risk of pancreatic cancer. International...
  • Lam, L., Sparnins, V. y Wattenberg, L. (1982). Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents...
  • Lancaster, T., Muir, J. y Silagy, C. (1994). The effects of coffee on serum lipids and blood presure in a UK population. Journal of the Royal...
  • LaVecchia, C., Franceschi, S., Decarli, A., Gentile, A., Liati, P., Regallo, M. y Tognoni, G. (1984). Coffee drinking and the risk of epithelial...
  • Lentini, A., Kleinman, H., Mattioli, P. et al. (1998). Inhibition of melanoma pulmonary metastasis by methylxanthines due to decreased invasion...
  • Lima, D. (1990). Coffee, a Medicinal Plant. New York: Vantage Press.
  • Lin, Y., Tamakoshi, A., Kawamura, T., Kikuchi, S., Motohashi, Y., Kurosawa, M., Ohno, Y. y JACC Study Group. (2002). Risk of pancreatic cancer...
  • Lipids Research Clinics Program. (1984). The lipids research clinics coronary primary prevention trial results. II. The relationship of reduction...
  • López Abente, G. y Escolar, A. (2001). Tobacco consumption and bladder cancer in non-coffee drinkers. Journal of Epidemiology and Community...
  • Lundsberg, L. (1998). Caffeine consumption. En G. Spiller (Ed.), Caffeine (pp. 199-224). Boca Ratón, Ca.:CRC.
  • MacMahon, B., Yen, S., Trichopoulos, D., Warren, K. y Nardi, G. (1981). Coffee and cancer of the pancreas. The New England Journal of Medicine,...
  • Mahmud, A. y Feely, J. (2001). Acute effect of caffeine on arterial stiffness and aortic pressure waveform. Hypertension, 38, 227-231.
  • Marchioli, R., Di Mascio, R., Marfisi, R. M., Vitullo, F. y Tognoni, G. (1996). Coffee intake and death from coronary heart disease (letter)....
  • Masedo, A. y Esteve, M. (2002). On the affective nature of chronic pain. Psicothema, 14, 511-515.
  • Meyer, K., Kushi, L., Jacobs, D., Slavin, J., Sellers, T. y Folsom, A. (2000). Carbohydrates, dietary fiber, and incident type 2 diabetes...
  • Michaud, D., Giovannucci, E., Willett, W., Colditz, G. y Fuchs, C. (2001). Coffee and alcohol consumption and the risk of pancreatic cancer...
  • Miller, D., Rosenberg, L., Kaufman, D., Helmrich, S., Schottenfeld, D., Lewis, J., Stolley, P., Rosenshlin, N. y Shapiro, S. (1987). Epithelial...
  • Miller, E., Formby, W., Rivera-Hidalgo, F. y Wright, J. (1988). Inhibition of hamster bucal pouch carcinogenesis by green coffee beans. Oral...
  • Miyake, Y., Kono, S., Nishiwaki, M., Hamada, H., Nishikawa, H., Koga, H. y Ogawa, S. (1999). Relationship of coffee consumption with serum...
  • Momas, I., Daures, J., Festy, B., Bontoux, J. y Gremy, F. (1994). Relative importance of risks factors in bladder carcinogenesis: Some new...
  • Moreno San Pedro, E. y Gil Roales-Nieto, J. (2003). El modelo de creen- cias de salud: revisión teórica, consideración crítica y propuesta...
  • Myers, M. y Basinski, A. (1992). Coffee and coronary heart disease. Archives on Internal Medicine, 152, 1.767-1.772.
  • Naismith, D., Akinyanju, P., Szanto, S. y Yudkin, J. (1970). The effect in volunteers of coffee and decaffeinated coffee on blood clotting....
  • NAS (1982). Committee on diet, nutrition and cancer ‘Diet, nutrition and cancer’ National Research Council. Washington, DC: National Academy...
  • Newby, D., Neilson, J., Jarvie, D. y Boon, N. (1996). Caffeine restriction has no role in the management of patients with symptomatic idiopathic...
  • Nieto, F., Comstock, G., Chambless, L. y Malinow, R. (1997). Coffee consumption and plasma homocyst(e)ine: results from the atheroesclerosis...
  • Nomura, A., Heilbrun, L. y Stemmermann, G. (1986). Prospective study of coffee consumption and the risk of cancer. Journal of the National...
  • Nurminen, M., Niittynen, L., Korpela, R. y Vapaatalo, H. (1999). Coffee, caffeine and blood pressure: a critical review. European Journal...
  • Nygard, O., Refsum, H., Ueland, P., Stensvold, I., Nordrehaug, J., Kvale, G. y Vollset, S. (1997). Coffee consumption and plasma total homocysteine....
  • Olthof, M., Hollman, P., Zock, P. y Katan, M. (2001). Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases...
  • Oshaug, A., Bugge, K. y Refsum, H. (1998). Diet, an independent determinant for plasma total homocysteine. A cross sectional study of Norwegian...
  • Partanen, T., Hemminki, K., Vainio, H. y Kauppinen, T. (1995). Coffee consumption not associated with risk of pancreas cancer in Finlad. Preventive...
  • Paul, O., Lepper, M.H., Phelan, W.H., Dupertuis, G.W., Macmillan, A. et al. (1963). A longitudinal study of coronary heart disease. Circulation,...
  • Pellicer, O., Salvador, A. y Benet, I. (2002). Efectos de un estresor académico sobre las respuestas psicológica e inmune en jóvenes. Psicothema,...
  • Phillips, R. y Snowdon, D. (1985). Dietary relationships with fatal colorectal cancer among Seventh-day Adventists. Journal of the National...
  • Pietinen, P., Geboers, J. y Kesteloot, H. (1988). Coffee consumption and serum cholesterol: An epidemiological study in Belgium. International...
  • Pirich, C., Ogrady, J. y Sinzinger, H. (1993). Coffee, Lipoproteins and cardiovascular-disease. Wiener Klinische Wochenschrift, 105, 3-6.
  • Pizziol, A., Tikhonoff, V., Paleari, C., Russo, E., Mazza, A., Ginocchio, G., Onesto, C., Pavan, L., Casiglia, E. y Pessina, A. (1998). Effects...
  • Polychronopoulou, A., Tzonou, A., Hsieil, C., Kaprinis, G., Rebelakos, A., Toupadaki, N. y Trichopoulos, D. (1993). Reproductive variables,...
  • Porta, M., Malats, N., Alguacil, J., Ruíz, L., Jariod, M., Carrato, A., Rifà, J. y Guarner, L. (2000). Coffee, pancreatic cancer, and K-ras...
  • Porta, M., Malats, N., Guarner, L., Carrato, A., Rifà, J., Salas, A., Corominas, J., Andreu, M., Real, F. y PANKRAS II Study Group. (1999)....
  • Pujolar, A., González, C., López Abente, G., Errezola, M., Izarzugaza, I., Nebot, M. y Riboli, E. (1993). Bladder cancer and coffee consumption...
  • Rachima-Maoz, C., Peleg, E. y Rosenthal, T. (1998). The effect of caffeine on ambulatory blood pressure in hypertensive patients. American...
  • Rakic, V., Burke, V. y Beilin, L.J. (1999). Effects of coffee on ambulatory blood pressure in older men and women. Hypertension, 33, 869-873.
  • Rebollo Arévalo, A. (2001). Estructura del Consumo en España. Madrid: Instituto Nacional del Consumo.
  • Refsum, H., Ueland, P., Nygard, O. y Vollset, S. (1998). Homocysteine and cardiovascular disease. Annual Review of Medicine, 49, 31-62.
  • Reunanen, A., Heliövaara, M. y Kimmo, A. (2003). Coffee consumption and risk of type 2 diabetes mellitus. Lancet, 361, 702-703.
  • Rosenberg, L., Slone, D., Shapiro, S., Kaufman, D.W., Stolley, P.D. y Miettinen, O.S. (1980). Coffee drinking and myocardial infarction in...
  • Ruiz del Castillo, M., Herráiz, M. y Blanch, G. (1999). Rapid analysis of cholesterol-elevating compounds in coffee brews by off-line high...
  • Ruiz Lapuente, M., Armadans Gil, L., Vaqué Rafart, J., Rosselló Urgell, J., Albertí Jaume, J. y Chacón Castro, P. (1995). Relación entre el...
  • Salazar Martínez, E., Willett, W., Ascherio, A., Manson, J., Leitzmann, M., Stampfer, M. y Hu, F. (2004). Coffee consumption and risk for...
  • Salmerón, J., Manson, J., Stampfer, M., Colditz, G., Wing, A. y Willett, W. (1997). Dietary fiber, glycemic load, and risk of non-insulin-dependent...
  • Sanguigni, V., Gallu, M., Ruffini, M.P. y Strano, A. (1995). Effects of coffee on serum cholesterol and lipoproteins: the Italian brewing...
  • Shearer, J., Farah, A., de Paulis, T., Bracy, D., Pencek, R., Graham, T. y Wasserman, D. (2003). Quinides of roasted coffee enhance action...
  • Shi, C. (1997). Effects of caffeine and acetylcholine on glucose-stimulated insulin release from islet transplants in mice. Cellular Transplant,...
  • Shirlow, M. J. y Mathers, C.D. (1984). Caffeine consumption and serum cholesterol levels. International Journal of Epidemiology, 13, 422-427.
  • Slattery, M., Caan, B., Anderson, K. y Potter, J. (1999). Intake of fluids and methylxantine-containing beverages: association with colon...
  • Slattery, M., West, D., Robinson, L. et al. (1990). Tobacco, alcohol, coffee, and caffeine as risk factors for colon cancer in a low-risk...
  • Snowdon, D. y Phillips, R. (1984). Coffee consumption and risk of fatal cancers. American Journal of Public Health, 74, 820-823.
  • Somoza, V., Lindenmeier, M., Wenzel, E., Frank, O., Erbersdobler, H. y Hofmann, T. (2003). Activity-guided identification of a chemopreventive...
  • Spiller, M. (1998). The chemical components of coffee. En G. Spiller (Ed.), Caffeine (pp. 97-161). Boca Raton, Ca.: CRC Press.
  • Spriet, L., McLean, D., Dick, D., Hultman, E., Caderblad, G. y Graham, T. (1992). Caffeine ingestion and muscle metabolism during prolonged...
  • Stensvold, I. y Jacobsen, B. (1994). A prospective study of 43,000 Norwegian men and women. Cancer Cause and Control, 5, 401-408.
  • Stensvold, I., Tverdal, A. y Jacobsen, B.K. (1996). Cohort study of coffee intake and death from coronary heart disease over 12 years. British...
  • Stolzenberg-Solomon, R., Miller, E., Maguire, M., Selhub, J. y Appel, L. (1999). Association of dietary protein intake and coffee consumption...
  • Superko, H.R., Bortz, W.J., Williams, P.T., Albers, J.J. y Wood, P.D. (1991). Caffeinated and decaffeinated coffee effects on plasma lipoprotein...
  • Tavani, A., Pregnolato, A., La Vecchia, C., Negri, E., Talamini, R. y Franceschi, S. (1997). Coffee and tea intake and risk of cancers of...
  • Terry, P., Bergkvist, L., Holmberg, L. y Wolk, A. (2001). Coffee consumption and risk of colorectal cancer in a population based prospective...
  • Thompson, W.G. (1994). Coffee: Brew of Bane? The American Journal of the Medical Sciences, 308, 49-57.
  • Thong, F., Derave, W., Kiens, B., Graham, T., Urso, B. Wojtaszewski, J., Hansen, B. y Richter, E. (2002). Caffeine-induced impairment of insulin...
  • Trichopoulos, D., Papapostolou, M. y Polychronopoulou, A. (1993). Coffee and ovarian cancer. International Journal of Cancer, 28, 691-693.
  • Tuomilehto, J., Tanskanen, A., Pietinen, P. et al. (1987). Coffee consumption is corrrelated with serum cholesterol in middle-aged Finnish...
  • Tzonou, A., Day, N., Trichopoulos, D., Walker, A., Saliaraki, M., Papapostolou, M. y Polychronopoulou, A. (1984). The epidemiology of ovarian...
  • Urgert, R., Essed, N., van der Weg, G., Kosmeijer-Schuil, T.G. y Katan, M.B. (1997). Separate effects of the coffee diterpenes cafestol and...
  • Urgert, R. y Katan, M.B. (1997). The cholesterol-raising factor from coffee beans. Annual Review of Nutrition, 17, 305-324.
  • Urgert, R., Kosmeijer-Schuil, T.G. y Katan, M.B. (1996). Intake levels, sites of action and excretion routes of the cholesterol-elevating...
  • Urgert, R., Meyboom, S., Kuilman, M., Rexwinkel, H., Vissers, M.N., Klerk, M. y Katan, M.B. (1996). Comparison of effect of cafetière and...
  • Urgert, R., Schulz, A. y Katan, M. (1995). Effects of cafestol and kahweol from coffee grounds on serum lipids and serum liver enzymes in...
  • Urgert, R., van Vliet, T., Zock, P. y Katan, M. (2000). Heavy coffee consumption and plasma homocysteine: A randomized control trial in healthy...
  • Urgert, R., Vanderweg, G., Kosmeijerschuil, T.G., Vandebovenkamp, P., Hovenier, R. y Katan, M.B. (1995). Levels of the cholesterol-elevating...
  • Urgert, R., Weusten-van der Wouw, M., Hovenier, R., Meyboom, S., Beynen, A. y Katan, M. (1997). Diterpenes from coffee beans decrease serum...
  • van Dam, R. y Feskens, E. (2002). Coffee consumption and risk of type 2 diabetes mellitus. Lancet, 360, 1.477-1.478.
  • van Rooij, J., Vanderstegen, G.H.D., Schoemaker, R.C., Kroon, C., Burggraaf, J., Hollaar, L., Vroon, T.F.F.P., Smelt, A.H.M. y Cohen, A.F....
  • Vena, J., Freudenheim, J., Graham, S., Marshall, J., Zielezny, M., Swanson, M. y Sufrin, G. (1993). Coffee, cigarette smoking and bladder...
  • Verhoef, P., Pasman, W., van Vliet, T., Urgert, R. y Katan, M. (2002). Contribution of coffeine to the homocysteine-raising effect of coffee:...
  • Vineis, P. (1999). ras Mutations and a cup of coffee: cause, confounder, effect modifier, or what else? Journal of Epidemiology and Community...
  • Viscoli, C., Lachs, M. y Horwitz, R. (1993). Bladder cancer and coffee drinking: a summary of case-control research. The Lancet, 341, 1.432-...
  • Vlachopoulos, C., Kosmopoulou, F., Sofianidou, A., Stefanadis, C., O’Rourke, M., Stamatelopoulos, S. y Toutouzas, P. (2003). Smoking while...
  • Wachmann, A., Hattner, R., George, B. y Bernstein, D. (1970). Effects of decaffeinated and nondecaffeinated coffee ingestion on blood glucose...
  • Wakabayashi, K., Kono, S., Shinchi, K., Honjo, S., Todoroki, I., Sakurai, Y., Umeda, T., Imanishi, K. y Yoshizawa, N. (1998). Habitual coffee...
  • Wei, M., Macera, C.A., Hornung, C.A. y Blair, S.N. (1995). The impact of changes in coffee consumption on serum cholesterol. Journal of Clinical...
  • Weusten-Van der Wouw, M., Katan, M., Viani, R., Huggett, A., Liardon, R., Lund-Larsen, P., Thelle, D., Ahola, I., Aro, A., Meyboom, S. y Beynen,...
  • Whelton, P.K. (1994). Epidemiology of hypertension. Lancet, 344, 101- 106.
  • Wittemore, A., Wu, M., Paffenbarger, R., Sarles, D., Kampert, J., Grosser, S., Jung, D., Ballon, S. y Hendrickson, M. (1988). Personal and...
  • Zeegers, M., Dorant, E., Goldbohm, R. y van der Brandt, P. (2001). Are coffee, tea, and total fluid consumption associated with bladder cancer...
  • Zeegers, M., Tan, F., Goldbohm, R. y van der Brandt, P. (2001). Are coffee and tea consumption associated with urinary tract cancer risk?...